Zubieta-Ruiz B, Sánchez-Márquez P, Castillo-Cruz RA

Language: Spanish
References: 27
Page: 220-225
PDF size: 179.64 Kb.

ABSTRACT

The objective of this study was to evaluate the impact of birth defects and genetic diseases in infancy as a health problem with respect to hospital care. We reviewed related articles from 1970 to 2007, from which 21 fulfill inclusion criteria. We conclude that genetic diseases and birth defects represent 40 to 50 percent of all admissions to pediatric centers and this number increases because of repeated hospitalizations of these patients. Birth defects and genetic diseases represent a public health problem related to epidemiologic transition. Further studies are needed to understand their implications in the future of health care system, the appropriate use of available resources, strategies, prevention, education of human resources and research.

REFERENCES

1. Perdigón VG, Fernández CB. Principales causas de muerte en la población general e infantil en México, 1922-2005. Bol Med Hosp Infant Mex 2008;65:238-40.

2. Venegas C, Peña-Alonso R, Lozano R, Kofman-Alfaro S, Queipo G. Mortalidad por defectos al nacimiento. Bol Med Hosp Infant Mex 2005;62:294-304.

3. www.conapo.gob.mx/publicaciones/1999/PDF/99002.pdf

4. www.inegi.org.mx/lib/buscador/busqueda.aspx?s=inegi

5. Mujeres y Hombres en México 2008. 12da edición. Instituto Nacional de Estadística, Geografía e Informática.

6. Instituto Nacional de Pediatría, Secretaría de Salud, México. Anuario Estadístico 2007.

7. Phillips B, Ball C, Sackett D, Badenoch D, Straus S, Haynes B, Dawes M. Oxford Centre for Evidence-based Medicine Levels of Evidence. 2001. /www.cebm.net/index.aspx?o=1025

8. Carter CO. Changing patterns in the causes of death at the Hospital for Sick Children. Great Ormond Street J 1956;11:65.

9. Roberts DF, Chávez J, Court SD. The genetic component in child mortality. Arch Dis Child 1970;45:33.

10. Lisker R, Armendares S. Prioridades de investigación en genética en Latinoamérica. Gaceta Méd Méx 1972;104:87.

11. Armendares S, Cortés R, De la rosa L. El componente genético en la mortalidad infantil. Rev Invest Clin (México) 1974;26:3.

12. Sánchez-Márquez P. El componente genético en la mortalidad infantil en el Hospital del Niño IMAN (tesis) Facultad de Medicina, Universidad Nacional Autónoma de México 1976.

13. Hall JG, Powers EK, McIlvaine RT, Ean VH. The frequency and financial burden of genetic disease in a pediatric hospital. Am J Med Genet 1978;1:417-36.

14. Scriver CR, Neal JL, Saginur R, Clow A. The frequency of genetic disease and congenital malformation among patients in a pediatric hospital. Can Med Assoc J 1973;108:1111-5.

15. Day N, Holmes LB. The incidence of genetic disease in a University Hospital population. Am J Hum Genet 1973;25:237-46.

16. Carnevale A, Hernández M, Reyes R, Paz F, Sosa C. The frequency and economic burden of genetic disease in pediatric hospital in Mexico City. Am J Med Genet 1985;20:665-75.

17. Ling EW. Frequency and load of congenital anomalies in a neonatal intensive care unit, prenatal diagnosis, and perinatal management. Semin Perinatol 1992;16:352-7.

18. Adeyemo AA, Gbadegesin RA, Omotade OO. Mayor congenital malformations among neonatal referrals to a Nigerian University Hospital. East Afr Med J 1997;74:699-701.

19. Moreno R, Aspillaga M, Avendaño I. Frequency and characteristics of genetic morbidity in a pediatric hospital. Rev Chil Pediatr 1991;62:112-7.

20. Yoon PW, Olney Rs, Khoury MT, Sappenfield WM, Chavez GF, Taylor D. Contribution of birth defects and genetic diseases to pediatric hospitalizations. A population-based study. Arch Pediatr Adolesc Med 1997;151:1096-103.

21. McCandless SE, Brunger JW, Cassidy SB. The burden of genetic disease on inpatient care in a children´s hospital. Am J Hum Genet 2004;74:788.

22. O´Malley M, Hutcheon RG. Genetic disorders and congenital malformations in pediatric long-term care. J Am Med Dir Assoc 2007;8:332-4.

23. Centers of Disease Control and Prevention. Infant mortality: United States, 1993. MMWRMorb Mortal Wkly Rep 1996;45:211-5.

24. Centers of Disease Control. Years of potential life lost before ages 65 and 85: United States, 1978 and 1988. MMWR Morb Mortal Wkly Rep 1990;39:20-2.

25. Juárez OS, Mejía JM, Rendón ME, Kauffman AN, Yamamoto LT, Fajardo AG. Tendencia de seis principales causas de mortalidad en niños mexicanos durante el período 1971-2000. La transición epidemiológica en los niños. Gac Méd Méx 2003;139:325-36.

26. Ortiz AM, Flores FG, Cardiel ML, Luna RJ. Frecuencia de malformaciones congénitas en el área de neonatología del Hospital General de México. Rev Mex Pediatr 2003;70(3):128-31.

27. Kofman AS, PenchaszadehVB. Community Genetic Services in Latin America and Regional Network of Medical Genetics. Recommendations of a World Health Organization Consultation. Community Genet 2004;7:157-9.