medigraphic.com
Órgano Oficial del Instituto Nacional de Pediatría

2009, Number 2

<< Back Next >>

Acta Pediatr Mex 2009; 30 (2)

Thrombocytopenia caused by ingestion of valproic acid. A problem for the stomatologist. Report of a case

Treviño-Carmona A, de la Teja-Ángeles E, Durán-Gutiérrez A, Mar-Aldana R

Language: Spanish
References: 25
Page: 109-113
PDF size: 36.47 Kb.


ABSTRACT

Any comprehensive medical treatment of systemically compromised children requires that the pediatric stomatologist identifi es any factor that might hinder or modify stomatologic procedures. We report the case of a 9-year old child who was being medicated with valproic acid (VPA). The patient suffered of quantitative and qualitative platelet alterations, and therefore had to receive replacement therapy prior to extraction of dental pieces. Any patient under anticonvulsant treatment must be thoroughly studied before any stomatologic procedure, in order to take necessary preventive actions.


REFERENCES

  1. Schwartz KA Immune disorders of platelets. En: Gross S, Roath S, eds. Hematology, a problem-oriented approach. Baltimore: Williams and Wilkins; 1996. p. 533-51.

  2. Bah M S,Actuación ante las anomalías cuantitativas y cualitativas de las plaquetas. Acta Bioquím Clín Latinoam 2005;39(3):347-53.

  3. Benito M. Manejo odontológico de pacientes con enfermedades hemorrágicas y terapia anticoagulante: Revisión bibliográfi ca. Acta Odontol Venez 2004;42(2):138-45.

  4. Bernardoni C. Manejo odontológico del paciente con trastornos hemorrágicos. Una revisión. Ciencia Odontol 2004;1(1): 60-70.

  5. Castillo R, Casals FJ Púrpuras trombopénicas y trombopáticas. En: Sans-Sabrafen J eds. Hematología clínica. 2a ed. Barcelona: Doyma; 1988. p. 581-97.

  6. Bithell TC. Qualitative disorders of platelet function. In: G.R. Lee TC, Bithell J, Foerster JW, Athens JN. Eds. Wintrobe´s Clinical Hematology, 9th Ed. Lukens, Philadelphia: Lea & Febiger; 1993. p. 1390-6.

  7. Warkentin TE, Trimble MS, Kelton JG. Thrombocytopenia due to platelet destruction and hypersplenism. En: Hoffman R, Benz EJ, Shatill SJ, Furie B, Cohen HJ, Silberstein LE, eds. Hematology. Basic principles and practice. 2a ed. Nueva York: Churchill Livingstone; 1995. p. 1849-70.

  8. Buchanan GR. Bleeding signs in children with idiopathic thrombocytopenic purpura. J Pediatr Hematol Oncol 2003;25:42– 6.

  9. McKenzie S. Trastornos de la hemostasia primaria. Hematología Clínica. 2da Edición México: Manual Moderno; 2001. p. 643-72.

  10. Murphy S. Trastornos plaquetarios: hereditarios y adquiridos. En: Mazza JJ. ed. Manual de hematología clínica. Barcelona: Salvat; 1990. p. 177-92.

  11. Burns MJ, Palmer BF. Management of valproic acid intoxication. Version 13.2. UpToDate Inc. USA: Wellesley; 2005. p. 450-65.

  12. Zaccara G, Messori A, Moroni F. Clinical pharmacokinetics of valproic acid. Clin Pharmacokinet 1988;15:367-89.

  13. Fernández MC, Walter FG, Kloster JC. Hemodialysis and hemoperfusion for treatment of valproic acid and gabapentin poisoning. Vet Hum Toxicol. 1996;38(6):438-43.

  14. British Committee for Standards in Haematology. Blood Transfusion Task Force. Guidelines for the use of platelet transfusions. Br J Haematol 2003;122:10-23.

  15. Radillo GA. Transfusión de plaquetas. Medicina Transfusional 2da. Edición. México: Ed. Prado; 2006. p. 495-509.

  16. Simpson J, Kinsey S. Paediatric transfusión. Vox Sanguinis 2001;81:1-5.

  17. Romero LD, Acosta BM, Bravo LA, et al. Transfusión en pediatría. Bol Med Hosp Inf Mex 2002;59:723-38.

  18. Roseff SD, Luban NLC, Manno CS, et al. Guidelines for assessing appropriateness of pediatric transfusion. Transfusion. 2002;42:1398-413.

  19. Brecher ME Neonatal and pediatric transfusion practice. En: Technical manual 15a. Edition. Bethesda MD: AABB Press; 2005. p. 557-80.

  20. Miyashiro AM, Dos Santos N, Guinsburg R, et al. Strict red blood guideline reduces the need for transfusions in very-low birthweight in the fi rst 4 weeks of life: a milticenter trial. Vox Sanguinis 2005;88:107-13.

  21. British Committe for Standards in Haematology. Blood transfusions Task force. Transfusion guidelines for neonates and older children. BR J Haematol. 2004;124:433-53.

  22. Wong ECC, Luban NLC. Intrauterine, neonatal, and pediatric transfusión. En: Mintz PD, editor. Transfusion therapy: clinical principles and practice 2ª. Edition. Bethesda MD: AABB Press; 2005. p. 159-201.

  23. Murray NA, Roberts IAG. Neontal transfusion practice. Arch Dis Child Neonatal 2004;89:101-7.

  24. American Society of Anestesiologists Task Force on Blood Component Therapy. Practice Guidelines for Blood Component Therapy. Anesthesiology 1996;84:732-47.

  25. Martinez-Murillo C, Quintana MS. Indicaciones clínicas de la transfusión. En: Radillo GA, editor. Medicina Transfusional.




2020     |     www.medigraphic.com