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2010, Number 5

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Cir Cir 2010; 78 (5)

Effective analgesic between acetominophen + B vitamins vs. acetominophen in pediatricambulatory surgery

Galván-Montaño A, Reyes-García G, Suárez-Roa ML, Asbun-Bojalil J

Language: Spanish
References: 34
Page: 400-409
PDF size: 360.03 Kb.


ABSTRACT

Background: Analgesics in pediatric ambulatory surgery must be safe and effective. Acetominophen is safe with moderate efficacy; therefore, we searched for other drugs. In preclinical trials, improved efficacy was reported with the combination of acetaminophen + B vitamins. The aim of this study was to determine the analgesic efficacy of acetaminophen + B vitamins in pediatric ambulatory surgery.
Methods: We conducted a clinical, comparative, randomized, double-blind study. We included 56 patients who were divided into four groups of 14 patients for each surgery (circumcision, tonsillectomy, inguinal hernioraphy, orchiopexy). Half of the patients received acetaminophen + B vitamins, and the remaining patients received acetaminophen alone. Variables were drugs, visual analogue scale and time of discharge. χ2, Student t-test and analysis of variance (ANOVA) were used for statistical analysis.
Results: In children who received acetaminophen + B vitamins during the immediate postoperative period, 58% had a pain score ≤2 and 89% were discharged with a pain score ≤1. Both schedules were effective and safe but acetaminophen + B vitamins showed a better pain score.
Conclusions: The adjuvant effect of B vitamins was demonstrated with a better pain score in the immediate postoperative period and at the time of discharge.


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