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Instituto Nacional de Salud Pública

2009, Number 3

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salud publica mex 2009; 51 (3)

Mechanisms of action of emergency contraception: pre and post-fertilization effects of levonorgestrel

Durand M, Larrea F, Schiavon R

Language: Spanish
References: 40
Page: 255-261
PDF size: 127.46 Kb.


ABSTRACT

There is still controversy regarding the mechanism of action of levonorgestrel (LNG) for emergency contraception (EC). For those who state that pregnancy starts prior to implantation, any compound able to interfere with post-fertilization and pre-implantation stages, should be considered as abortifacient. Previous research suggests that EC in humans acts predominantly after fertilization. Current evidence with LNG-only EC supports a pre-fertilization mechanisms to explain its action. There are many potential mechanisms of action, which could vary pending on the day during the fertilization window of the ovarian cycle at which the contraceptive is given. This paper reviews the evidence for each potential mechanism of action. According to the most recently statements, it is concluded that the primary and possible the only mechanism of action of LNG-only EC is preventing or delaying ovulation.


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