Velarde FJS, Cázarez SSG, Castro VR, Rendón MJG, Rangel VH

Language: Spanish
References: 16
Page: 59-61
PDF size: 192.81 Kb.

ABSTRACT

Objetive. To establish the association of the vitamin D receptor gene TaqI polymorphism with lepromatous leprosy (LL) in individuals from Sinaloa, Mexico. Material and Methods. A 740 bp fragment was amplified from the VDR gene in DNA samples of 71 patients with LL and 144 controls in the Hospital General de Culiacán during 2004-2007. Polymorphism was identified through TaqI endonuclease. Results. A significant increase in the genotype TT of the VDR gene was observed in patients when compared to controls (p = 0.040; OR = 1.82). Conclusions. Our data support the association between the TT genotype and susceptibility to LL in this Mexican population.

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