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2002, Number 5

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Rev Med Inst Mex Seguro Soc 2002; 40 (5)

Neuroprotector Strategies After Traumatic Spinal Cord Injury

Díaz RA, Guízar SG, Ríos CC

Language: Spanish
References: 110
Page: 437-455
PDF size: 177.45 Kb.


ABSTRACT

Traumatic injury of the spinal cord is a health problem affecting mainly the adult population with an annual incidence of approximately 20 cases per million inhabitants. At present, there is no strategic therapy effective for reestablishing neurologic function, due to the complexity of regulating mechanisms of secondary damage and poor capacity of expontaneous regeneration of the mature central nervous system. There are many studies describing physiopathologic mechanisms after injury and on the basis of this background, the problem has been faced by proposing the use of several drugs such as methylprednisolone, the drug of choice for patients with spinal traumatism. Studies with animals have supported the use of antagonist of NMDA receptor to counteract the excitotoxic effect leading to cell death, free radical scavenger to modulate the oxidative stress (mexylatin and OPC-14117), and immunosuppressors (cyclosporin-A and tacrolimus) among others. On the other hand, cell transplant and glial cell transplant seems to be a good alternative to favor processes of axonal regeneration. Finally, increasing synthesis and secretion of different trophic factors is important to recover neurologic function.


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