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Órgano Oficial de la Asociación Mexicana de Infectología Pediátrica y la SLIPE.

2005, Number 72

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Rev Enfer Infec Pediatr 2005; 18.19 (72)

Chicken pox treatment with oral and spray aciclovir presentation at private practice in mexican children

Castañeda NJL, Lago AA

Language: Spanish
References: 21
Page: 112-116
PDF size: 148.66 Kb.


ABSTRACT

Objective. To know the efficacy and safety of oral and spray acyclovir in the treatment of chickenpox in pediatric patients.
Material and Methods. 328 pediatric patients diagnosed with chickenpox by 203 doctors at national level. Acyclovir was administered orally 400 mg four times a day in children aged 2 to 6 years, and 800 mg in children aged 6 years and older. Acyclovir spray was administered to each lesion four times a day.
Results: Findings from visit 1 (entrance), visit 2 (fifth day from chickenpox start), and visit 3 (Day 14) were reported. Decreases in vesicle eruption of 15.57% in frontal region (p‹0.001), and 11.84% (p‹0.001) in the dorsal region were observed. Regarding lesion intensity, lesion severity decreased from Visit 1 to Visit 2, from 10.68% to 1.85% (p‹0.001) on the face, 4.10 to 1.40% (p‹0.001) on the neck, 10.29 to 1.66% (p‹0.001) on the arms (see Table 2), from 21.66 to 3.52% (p‹0.001) on thorax, from 22.37 to 5.00% (p‹0.001) on back, and from 9.77 to 2.10% (p‹0.001) on legs. Slight acyclovir adverse events were observed in 5.59%. At physician’s opinion, acyclovir improved patient’s status in 96.94%.
Conclusion. This study suggests that the use of oral and spray acyclovir is efficient and safe for treating chickenpox in children, reducing both, cutaneous number, and lesion intensity.


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