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2005, Number 71

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Rev Enfer Infec Pediatr 2005; 18.19 (71)

Pandemics of Influenza

Carrada BT

Language: Spanish
References: 17
Page: 66-71
PDF size: 114.38 Kb.


ABSTRACT

Researchers have demonstrated that influenza epidemics have affected humans for many centuries. Epidemiologists have developed sophisticated means of tracking the virus activity around the globe, in order to detect the prevalent subserotypes. Viral surveillance helps vaccine’s manufacturers to design the appropriate A and B composition to control the impending epidemics, and to measure its toll in terms of morbidity-mortality. Influenza is on going public health issue because the virus ability to continually reinvent itself. Antigenic drift caused by subtle changes in viral surface proteins, partially accounts for annual epidemic outbreaks of the illness. Antigenic shift occurs because major changes in the viral haemagglutinin and sometimes in the neuraminidase, which results in widespread and lethal pandemics. Moreover, type A influenza is a zoonosis, and by understanding how both of, these changes occur in waterfowl, the virus primary host, scientist can develop both drugs and preventive strategies to avert or minimize the most severe effects of influenza.


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