2009, Number 5
<< Back Next >>
Med Int Mex 2009; 25 (5)
Función cognitiva y factores cardiometabólicos en diabetes mellitus tipo 2
Cervantes-Arriaga A, Calleja-Castillo J, Rodríguez-Violante M
Language: Spanish
References: 71
Page: 386-392
PDF size: 303.76 Kb.
ABSTRACT
Background: Cognitive decline in diabetes mellitus type 2 is well recognized; its etiology is complex due to the diversity of physiopathologic mechanisms potentially involved as well as the high prevalence of comorbility including hypertension, obesity and dyslipidemia.
Material and Method: In the review we present recent evidence regarding risk factors related with congnitive decline in diabetic population. Risk factors reviewed included glycemic control, insulin resistance but also obesity, hypertension and metabolic syndrome.
Results: Cognitive decline in diabetic patients appear to be mainly related with glycemic control.
Conclusion: Current evidence suggests a multifactorial etiology with uncontrolled chronic glycemia and HbA1c as a marker standing out. Nevertheless, an integral treatment of comorbilities and regular evaluations of cognitive function are required.
REFERENCES
Cicconetti P, Riolo N, Priami C, et al. Risk factors for cognitive impairment. Recenti Prog Med 2004;95(11):535-45.
Tilvis RS, Kahonen-Vare MH, Jolkkonen J, et al. Predictors of cognitive decline and mortality of aged people over a 10-year period. J Gerontol A Biol Sci Med 2004;59(3):268-74.
Sima AA, Kamiya H, Li ZG. Insulin, C-peptide, hyperglycemia and central nervous system. Eur J Pharmacol 2004;490(1- 3):187-97.
Biessels GJ, Kerssen A, de Haan EH, Kappelle LJ. Cognitive dysfunction and diabetes: implications for primary care. Prim Care Diabetes 2007;1:187-93.
Kodl CT, Seaquist ER. Cognitive dysfunction and diabetes mellitus. Endocr Rev 2008;29:494-511.
Bauduceau B, Bourdel-Marchasson I, Brocker P, Taillia H. The brain on the elderly diabetic patient. Diabetes Metab 2005;31(2)5S92-5S97.
Messier C. Impact of impaired glucose tolerance and type 2 diabetes on cognitive aging. Neurobiol Aging 2005;26(suppl 1):26-30.
Launer LJ. Diabetes and brain aging: epidemiologic evidence. Curr Diab Rep 2005;5(1):59-63
Cuckierman T, Gerstein HC, Williamson JD. Cognitive decline and dementia in diabetes -systematic overview of prospective observational studies. Diabetologia 2005;48(12):2460-9.
Shcnaider BM, Goldbourt U, Silverman JN, et al. Diabetes mellitus in midlife and the risk of dementia three decades later. Neurology 2004;63(10):1902-7.
Hassing LB, Grant MD, Hofer SM, et al. Type 2 diabetes mellitus contributes to cognitive decline in old age: a longitudinal population based study. J Int Neuropsychol Soc 2004;10(4):599-607.
Messier C, Awad N, Gagnon M. The relationships between atherosclerosis, heart disease, type 2 diabetes and dementia. Neurol Res 2004;26(5):567-72.
Arvantiakis Z, Wilson RS, Bienias JL, et al. Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function. Arch Neurol 2004;81(5):661-6.
Allen KV, Frier BM, Strachan MW. The relationship between type 2 diabetes and cognitive dysfunction: longitudinal studies and their methodological limitations. Eur J Pharmacol 2004;490(1-3):169-75.
Liang XC, Guo SS, Hagino N. Current status of clinical and experimental researches on cognitive impairment in diabetes. Chin J Integr Med 2006;12(1):68-74.
Gallacher JE, Pickering J, Elwood PV, et al. Glucoregulation has greater impact on cognitive perfromance than macrovascular disease in men with type 2 diabetes: data from the Caerphilly study. Eur J Epidemiol 2005;20(9):761-8.
Cox DJ, Kovatchev BP, Gonder-Frederick LA, et al. Relationships between hyperglycemia and cognitive perfromance among adults with type 1 and type 2 diabetes. Diabetes Care 2005;28(1):71-7.
Sommerfiled AJ, Deary IJ, Frier BM. Acute hyperglycemia alters mood state and impairs cognitive perfromance in people with type 2 diabetes. Diabetes Care 2004;27(10):2335-40.
Arvaitakis Z, Wilson RS, Li Y, et al. Diabetes and function in different cognitive systems in older individuals without dementia. Diabetes Care 2006;29(3):560-5.
Ryan CM, Freed MI, Rood JA, et al. Improving metabolic control leads to better working memory in adults with type 2 diabetes. Diabetes Care 2006;29(2):345-51.
Strachan MW. Insulin and cognitive function in humans: experimental data and therapeutic considerations. Biochem Soc Trans 2005;33(5):1037-40.
De la Monte SM, Wands Jr. Review of insulin and insulin-like growth factor expression, signaling and malfunction in the central nervous system: relevance to Alzheimer’s disease. J Alzheimers Dis 2005;7(1):45-61.
Mussell M, Hewer W, Kulzer B, Bergis K. Effects of improved glycemic control. Diabet Med 2004;21(11):1253-6.
Qiao QW, Lyn PL, Hibberd P, et al. Executive dysfunction in homebound older people with diabetes mellitus. J Am Geriatr Soc 2006;54(3):496-501.
Kouta Y, Sakurai T, Yokono K. Cognitive dysfunction and dementia associated with elederly diabetes. Nippon Rinsho 2006;64(1):119-23.
Awad N, Gagnon M, Messier C. The relationship between impaired glucose tolerance, type 2 diabetes and cognitive function. J Clin Exp Neuropsychol 2004;26(8):1044-80.
Trudeau F, Gagnon S, Massicotte G. Hippocampal synaptic plasticity and glutamate receptor regulation: influences of diabetes mellitus. Eur J Pharmacol 2004;490(1-3):177-86.
Huber JD. Diabetes, cognitive function, and the blood-brain barrier. Curr Pharm Des 2008;14:1594-600.
Munshi M, Grande L, Hayes M, et al. Cognitive dysfunction is associated with poor diabetes control in older adults. Diabetes Care 2006; 29:1794-99.
Barrou Z, Lemaire A, Boddaert J, Verny M. Diabetes mellitus and cognition: is there a link? Psychol Neuropsychiatr Vieil 2008;6:189-98.
Roberts RO, Geda YE, Knopman DS, Christianson TJ, et al. Association of duration and severity of diabetes mellitus with mild cognitive impairment. Arch Neurol 2008;65:1066-73.
Bruce DG, Davis WA, Casey GP, et al. Predictors of cognitive decline in older individuals with diabetes. Diabetes Care 2008; 31:2103-7.
Williamson JD, Miller ME, Bryan RN, et al. The Action to Control Cardiovascular Risk in Diabetes Memory in Diabetes Study (ACCORD-MIND): rationale, design, and methods. Am J Cardiol 2007;99(12A):112i-122i
Lustman PJ, Clouse RE. Depression in diabetic patients: the relationship between mood and glycemic control. J Diabetes Complications 2005;19(2):113-22.
Jorm AF, Anstey KJ, Christensen H, et al. MRI hyperintensities and depressive symptoms in a community sample of individuals 60-64 years old. Am J Psychiatry 2005;162:699-705.
Biessels GJ, Koffeman A, Scheltens P. Diabetes and cognitive impairment: Clinical diagnosis and brain imaging in patients attending a memory clinic. J Nuerol 2005;253(4):477-82.
Schmidt R, Launer LJ, Nilsson LG, et al. Magnetic resonance imaging of the brain in diabetes: the cardiovascular determinants of dementia (CASCADE) study. Diabetes 2004;53(3):687-92.
Manschot SM, Brands AM, van der Grond J, et al. Brain magnetic resonance imaging correlates of impaired cognition in patients with type 2 diabetes. Diabetes 2006;55(4):1106-13.
Akisaki T, Sakurai T, Takata T, et al. Cognitive dysfunction associates with white matter hyperintensities and subcortical atrophy on magnetic resonance imaging of the elderly diabetes mellitus in Japanese elderly. Diabetes Metab Res Rev 2006;22(5):376-84.
Teral S. A neuroradiological study on the influence of cerebral atrophy and white matter lesion on cognitive funtion in the elderly. Nippon Ronen Igakkai Zasshi 2004;41(5):521-7.
Lazarus R, Prettyman R, Cherryman G. White lesions on magnetic resonance imaging and their relationship with vascular risk factors in memory clinic attenders. Int J Geriatr Psychiatry 2005;20(3):274-9.
Van Harten B, Oosterman J, Muslimvic D, et al. Cognitive impairment and MRI correlates in the elderly patients with type 2 diabetes mellitus. Age Ageing 2007;36:164-70.
Manschot SM, Biessel GJ, de Valk H, et al. Metabolic and vascular determinants of impaired cognitive performance and abnormalities on brain magnetic resonance imaging in patients with type 2 diabetes. Diabetologia 2007;50:2388-97.
Van den Berg E, Kloppenberg RP, Kessels R, et al. Type 2 diabetes mellitus, hypertension, dyslipidemia and obesity: A systematic comparison of their impact on cognition. Biochim Biophys Acta 2008; In Press
Van den Berg E, Kessels RPC, Kappelle LJ, et al. Type 2 diabetes, cognitive function and dementia: Vascular and metabolic determinants. Drugs Today 2006;42:741.
Dou JT, Chen M, Dufour F, et al. Insulin receptor signaling in long-term memory consolidation following spatial learning. Learn Mem 2005;12(6):646-55.
Starr VL, Convit A. Diabetes, sugar-coated but harmful to the brain. Curr Opin Pharmacol 2007;7:638-42.
Neumann KF, Rojo L, Navarrete LP, et al. Insulin resistance and Alzheimer’s disease: molecular links and clinical implications. Curr Alzheimer Res 2008;5:438-47.
Zhao WQ, Chen H, Quon MJ, Alkon DL. Insulin and the insulin receptor in experimental models of learning and memory. Eur J Pharmacol 2004;490(1-3):71-81.
Convit A. Links between cognitive impairment in insulin resistance: an explanatory model. Neurobiol Aging 2005;26(suppl 1):31-5.
Li ZG, Zhang W, Sima AA. The role of impaired insulin/ GF action in primary diabetic encephalopathy. Brain Res 2005;1037(1-2):12-24.
Reagan LP. Neuronal insulin signal transduction mechanisms in diabetes phenotypes. Neurobiol Aging 2005;26(suppl 1):56-9.
Okereke O, Hankinson SE, Hu FE, Grostein F. Plasma C peptide level and cognitive function among older women without diabetes mellitus. Arch Intern Med 2005;165(14):1651-6.
Mogi N, Umegaki H, Hattori A, et al. Cognitive function in Japanese elderly with type 2 diabetes mellitus. J Diabetes Complications 2004;18(1):42-6.
Geroldi C, Frisoni GB, Paolisso G, et al. Insulin resistance in cognitive impairment: the in CHIANTI study. Arch Neurol 2005;62(7):1067-72.
Yaffe K, Blackwell T, Kanaya AM, et al. Diabetes, impaired fasting glucose and development of cognitive impairment in older women. Neurology 2004;63(4):658-63.
Kumari M, Marmot M. Diabetes and cognitive function in a middle-aged cohort: findings from the Whitehall II study. Neurology 2005;65(10):1597-603.
Farr SA, Banks WA, Morley JE. Effects of leptin on memory processing. Peptides 2006;27(6):1420-5.
Elias MF, Elias PK, Sullivan LM, Wolf PA, Dagostino RB. Obesity, diabetes and cognitive deficit: The Framingham Heart Study. Neurobiol Aging 2005;26 (suppl 1):11-6.
Singh-Manoux A, Marmot M. High blood pressure was associated with cognitive function in middle-age in the Whitehall II Study. J Clin Epidemiol 2005;58(12):1308-15.
Kuo HK, Jones RN, Milberg WP, et al. Effect of blood pressure and diabetes mellitus on cognitive and physycal functions in older adults: a longitudinal analysis of the advanced training for independent and vital elderly cohort. J Am Geriatr Soc 2005;53(7):1154-61.
Pavlik VN, Hyman DJ, Dood R. Cardiovascular risk factors and cognitive function in adults 30-59 years of age (NHANES III). Neuroepidemiology 2005;24(1-2):42-50.
Hassing LB, Hofer SM, Nilsson SE, et al. Comorbid type 2 diabetes mellitus and hypertension exacerbates cognitive decline: evidence from a longitudinal study. Age Ageing 2004;33(4):355-61.
Vicario A, Martinez CD, Baretto D, et al. Hypertension and cognitive decline: impact on executive function. J Clin Hypertens 2005;7(10):598-604.
Warren RE, Frier BM. Hypoglycaemia and cognitive function. Diabetes Obes Metab 2005;7(5):493-503.
Taylor VH, MacQueen GM. Cognitive dysfunction associated with metabolic syndrome. Obes Rev 2007;8:409-18
Yaffe K. Metabolic syndrome and cognitive disorders. Alzheimer Dis Assoc Disord 2007;21:167-71.
Ho RC, Niti M, Yap KB, et al. Metabolic syndrome and cognitive decline in chinese older adults: results from the Singapore longitudinal Study. Am J Geriatr Psychiatry 2008;16:519-22.
Gatto NM, Henderson VW, St John JA, et al. Metabolic syndrome and cognitive function in healthy middle-aged and older adults without diabetes. Neuropsychol Cogn 2008;15:627-41.
Van den Berg E, Biessels GJ, de Craen AJ, et al. Neurology 2007; 69:979-85
Laudisio A, Marzetti E, Pagano F, et al. Association of metabolic syndrome with cognitive function: the role of sex and age. Clin Nutr 2008; 27:747-54.