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Colegio de Medicina Interna de México.

2009, Number 4

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Med Int Mex 2009; 25 (4)

Neuroendocrine dysfunction in the patient with neurological critical state

Carrillo ER, Castro PJF

Language: Spanish
References: 41
Page: 270-277
PDF size: 323.22 Kb.


ABSTRACT

Introduction: In Mexico, traumatic brain injury is a public health problem and the thirth cause of death. The neuroendocrine dysfunction associated to traumatic brain injury is a common cause of increased morbimortality and a negative response to rehabilitation.
Patients and methods: Patients with acute neurologic illnes that were admitted to the intensive care unit (ICU) of the Hospital of the Clinical foundation Médica Sur. Basal determinations of hipofiseal hormones at admittance, at 36 hours and at 48 hours.
Results: 5 patients with acute neurological illness. Three patients with traumatic brain injury, one patient with primary CNS vasculitis, one patient with subarachnoid haemorrhage associated with aneurysm rupture. All patients presented neuroendocrine dysfunction with variable grades predominantly central hypotiroidism, hypogonadotrophic hypogonadism and hyperprolactinemia.
Conclusions: The neuroendocrine dysfunction is associated with increase in the morbimortality and negative impact in the response to the rehabilitation. To Increase awareness, and to know an approach mode and screening of this clinical entity is imperative for the multidiciplinary group involucrated with this patients.


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