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Colegio de Medicina Interna de México.

2009, Number 1

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Med Int Mex 2009; 25 (1)

Relation between hours of sleep and metabolic syndrome

Juárez RE, Jiménez SN, Lozano NJJ, Fernández AM

Language: Spanish
References: 22
Page: 9-16
PDF size: 688.5 Kb.


ABSTRACT

Background: The metabolic syndrome represents a clustering of several interrelated risk factors of metabolic origin that are thought to increase cardiovascular risk. It is still uncertain whether this clustering results from multiple underlying risk factors or whether it has a single cause. The evidence suggests that restricting sleep adversely affects metabolism. The restriction of sleep can damage glucose tolerance, alter levels of leptin and ghrelin increasing hunger and appetite, especially for foods with high carbohydrates content dense favouring the development of metabolic syndrome.
Objective: To assess the relationship between hours of sleep, the components of the metabolic syndrome and the role of guard ABC, among residents of two health institutions.
Methods: According to the criteria of the third report of the national cholesterol education program (NCEP-ATP III) designed a case-control study in two health institutions. 65 residents of second year or more, 33 with guards ABC Secretary of Health of the Government of Mexico City (SSDF) and 32 of specialties that do not have this complementary medical practice General Hospital of Mexico (HGM) for the period from March to May of 2008; was informed each resident, and after their acceptance was to collect information on the document, was given blood pressure, waist circumference, weight, height, BMI. Extraction fasting blood of least 8 hours to determine glucose levels, HDL cholesterol, triglycerides, and fasting insulin levels.
Results: With less than five hours of sleep a day, as well as with more than eight, a higher susceptibility to have metabolic syndrome was found. Metabolic health status found in residents was: Obese BMI ≥ 27, the overall incidence was 40%, 54.5% and 25% in the group exposed and unexposed respectively with an odds ratio of 3.86 (95% CI 1.31 to 11.46) p= 0.01. Levels of triglycerides, with an odds ratio of 3.36 (95% CI 1.13 to 10.29) p= 0.02, hours of sleep, with an odds ratio of 2.82 (95% CI 0.97 to 8.33) p= 0.04; women with waist circumference, with an odds ratio of 18.0 (95% CI 2.25 to 158) p= 0.003, men with an odds ratio of 6.48 (95% CI 1.27 to 35.99) p= 0.02. Levels of HDL cholesterol women, an odds ratio of 1.33 (95% CI from 0.24 to 7.42) p= 1.00, men with an odds ratio of 1.38 (95%CI from 0.31 to 6.56) p= 0.02. Levels of insulin, an odds ratio of 4.80 (95% CI from 2.11 to 10.07) p= 0.05, HOMA an odds ratio of 5.54 (95% CI from 2.66 to 20.54) p= 0.12
Conclusion: The resident exposed to guards ABC has high incidence of obesity and metabolic syndrome, with an increased risk of 2.5 and 2.8 respectively. The sleep duration (≤ 5h) associated with the metabolic syndrome 1.8 greater risks in the exposed group; the associate hyperinsulinemia was 3.8 higher risks in the exposed group. We did not found direct relation between HOMA and guards ABC in this study.


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