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2010, Number 1

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Cir Cir 2010; 78 (1)

Valor pronóstico de los niveles de interleucina-6 en pacientes con infarto agudo del miocardio con elevación del segmento ST

Borrayo-Sánchez G, Pacheco-Bouthillier A, Mendoza-Valdez L, Isordia-Salas I, Argüero-Sánchez R, Careaga RG

Language: Spanish
References: 34
Page: 23-30
PDF size: 200.20 Kb.


ABSTRACT

Background: Interleukin-6 (IL6) plays a role in atherogenesis as well as in most atherothrombotic phenomenon such as the ST-segment elevation acute myocardial infarction (STEAMI). Our objective was to evaluate serum levels of IL6 as prognostic value for major clinical in-hospital events in patients with STEAMI.
Methods: We studied consecutive patients with diagnosis of STEAMI according to ACC/AHA/ESC criteria. Twenty four hours after the acute event, IL6 was determined by chemoluminescence method. The major cardiovascular end point was arrhythmias, angina, heart failure, reinfarction and death.
Results: Included were 97 patients. The level of IL6 to identify high-risk patients was 20 pg/ml. Forty six patients had ‹ 20 pg/ml (group I), and 51 patients had ›20 pg/ml (group II). Mean value of IL6 was 11.52 ± 4.83 pg/ml vs. 63.19 ± 44.4 pg/ml (p ‹ 0.0001). Death was more frequent (2.2 vs. 15.7%, p = 0.023, RR 1.16 95% CI 1.02-1.31) and the end point combined during hospitalization in group II was 21.7 vs. 51% (p = 0.003 RR 1.59 95% CI 1.16-2.19). Multivariate logistic regression analysis identified Killip class ≥2 and IL6 levels ≥20 pg/ml as predictors for in-hospital end point.
Conclusions: Serum levels of IL6 ›20 pg/ml in the first 24 h after STEAMI were significantly associated with higher frequency of in-hospital outcomes such as arrhythmias and death.


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