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2003, Number 2

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Rev Med Inst Mex Seguro Soc 2003; 41 (2)

Efficiency of Oral, Nasal Midazolam or Chloral Hydrate Children During Ecocardiographic Procedures

Huchim ALM, Sierra BG, Fernández BV

Language: Spanish
References: 21
Page: 121-126
PDF size: 117.75 Kb.


ABSTRACT

Objective: To compare efficiency between two sedatives at beginning of good action, time of recovery, and undesirable effects during echocardiography studies. Design: Controlled clinical trial. Location: National Medical Center “Ignacio Garcia Tellez”, Social Security Mexican Institute, Merida, Yucatan, Mexico. Material and methods: Sample: 150 children aged from newborns to 15 months were randomized into one of three groups: oral midazolam plus nasal placebo; nasal midazolam plus oral placebo; chloral hydrate plus nasal placebo. The optimal time of sedation was measured (Wilton scale), time of recovery after having finished the study, and presence of undesirable effects. Pulse oximetry, saturation of O2, and heart frequency were measured before, during and after the study. Results: We found significant differences in time in reaching optimal sedation (3-4 Wilton scale) with nasal midazolam 9.1 ± 6 min; oral midazolam with 10.8 ± 5.9 min, and with chloral hydrate 19.7 ± 13.8 min. The proportion of children who reached a good sedation degree was for oral and nasal midazolam 88 %, with chloral hydrate 68 % (p ‹ 0.05). The least time of recovery was for nasal midazolam 29.4 ± 17.1. Oral midazolam 43.08 ± 32.9 min continued and lastly chloral hydrate 97.5 ± 56.2 min, p ‹ 0.05. Conclusions: Results of this work showed more efficient nasal and oral midazolam than chloral hydrate in sedation of pediatric patients for studies of echocardiography in terms of desirable sedation degree, lessen time of recovery, and without undesirable side effects.


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