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ISSN 0188-9796 (Print)

2010, Number 1

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Rev Endocrinol Nutr 2010; 18 (1)

Differentiated thyroid cancer in a pediatric population. Experience at the Hospital de Pediatría, Centro Médico Nacional Siglo XXI, IMSS

Rivera-Hernández A, López-Beltrán AL, Nishimura-Meguro E, Garrido-Magaña E

Language: Spanish
References: 19
Page: 30-33
PDF size: 167.45 Kb.


ABSTRACT

Background and objective: Differentiated thyroid carcinoma (DTC) represents 90-95% of cases of thyroid cancer. Approximately 2% of newly diagnosed patients are less than 20 years of age. The objective of this study was to report the clinical behavior of DTC in our pediatric population. Material and methods: We reviewed the files of patients with DTC followed at the Endocrinology Department of Hospital de Pediatria of CMN Siglo XXI, from January 2009 to February 2010. We recollected demographic data, clinical features at the moment of diagnosis, treatment with radioiodine and outcome. Results: We included 10 female and 6 male patients; the median age at diagnosis was 11.5 years. The most common clinical presentation was thyroid nodule (68.75%) and regional lymph nodes in 90% of the cases. The histopathology was papillary carcinoma in 94% (13.5% had subtypes with worse prognosis) with only one case of follicular carcinoma; 50% presented metastases. During follow–up we found residual disease in 75% of the patients, additional RAI therapy was necessary (131I average cumulative doses was of 235 mCi). TSH was suppressed in 70% of the cases. Conclusion: The clinical behavior of these patients, compared with other series reported in literature, shows a higher incidence of local invasion and metastases at the moment of diagnosis, probably due to the delay in referral to our hospital.


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