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2010, Number 2

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Rev Mex Anest 2010; 33 (2)

Propofol infusion syndrome

Carrillo-Esper R, Garnica-Escamilla MA, Bautista-León RC

Language: Spanish
References: 46
Page: 97-102
PDF size: 221.01 Kb.


ABSTRACT

Propofol infusion syndrome (PRIS) is a rare but potentially lethal complication after long-term, high-dose propofol infusion. This disorder is triggered under unknown circumstances by a propofol infusion of more than 4 mg/kg/h for more than 48 h. PRIS is characterized by a multiorgan failure, rhabdomyolysis, metabolic acidosis, hyperkalemia, arrhythmias and sudden cardiac death. Is induced by a disturbance in mitochondrial long chain fatty acid oxidation. The treatment of PRIS is discontinuation of propofol, rapid correction of lactic acidosis, hyperkalemia and rhabdomyolisis and cardiovascular support.


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