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Revista Latinoamericana de Microbiología

2008, Number 3-4

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Microbiología 2008; 50 (3-4)

Some aspects of the genetic organization and regulation in Trypanosoma cruzi: The etiologic agent of chagas disease

Gómez GA, Monteón PVM

Language: Spanish
References: 92
Page: 103-118
PDF size: 192.04 Kb.


ABSTRACT

Trypanosoma cruzi infection and Chagas disease have been recognized as endemic problem in some areas of México, its etiologic agent, the T. cruzi parasite shows a clonal behavior with particular genetic characteristics within populations. In the present work we review some significant aspects of T. cruzi such as its genomic organization, transcription and post-transcriptional mechanisms. T. cruzi is an eukaryotic micro-organism with highly repeated sequences in its genome, their genes are tandem accommodated and interrupted by short intergenic spaces, and only few promoter sequences have been identified at the moment. A primary polycistronic RNA without introns that maturate by a trans-splicing mechanism with differential gene expression regulated basically at the post-transcriptional level.


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