Hernández NL, Álvarez CA, Gómez N, Castorena I, Pedroza MÁ, Huerta LJG

Language: Spanish
References: 27
Page: 121-125
PDF size: 55.20 Kb.

ABSTRACT

During the repeated administration of any drug, all patients are susceptible of hypersensitivity reactions, thus meriting its suspension. However, there are special cases in which some drugs must be continued in the absence of other treatment options, considering the desensitization a method to achieve it. Hypersensitivity to certain antineoplastics led to the creation of new drugs with lower immunogenicity to avoid it, however in countries where they are not available, desensitization protocols are extremely important to complete the treatment of those patients who have had a reaction mediated by antibodies. We present a case of a pediatric patient with acute lymphoblastic leukemia and an anaphylactic reaction to L-asparaginase that requires the readministration of the drug to complete induction phase in his second relapse.

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