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2009, Number 4

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Rev Med Hosp Gen Mex 2009; 72 (4)

Alcoholic hepatitis

Higuera-de la Tijera MF, Pérez-Hernández JL, Servín-Caamaño AI, Serralde-Zúñiga AE, Cruz-Palacios A, Abdo-Francis JM, Bernal-Sahagún F, Salas-Gordillo F

Language: Spanish
References: 42
Page: 215-221
PDF size: 101.53 Kb.


ABSTRACT

Alcohol is a direct hepatic toxin. 10 to 20% of alcoholics develops Alcoholic Hepatitis, this imply a complex interaction between facilitating factors and comorbidity like gender, hereditary factors and immunity. Alcoholic Hepatitis origins for the ethanol great intake besides the long time intake and can manifest for moderate to severe steatosis; in general, the last one with great mortality. Several organs are capable to metabolize the ethanol, although the liver is who has the more specific enzymatic systems. Within physiopathology, tumor necrosis factor–alpha plays an important role in develop of hepatic damage induced by ethanol. Alcohol Hepatitis is associated with an ample spectrum of clinic manifestations. To estimate prognosis we sort the Maddrey’s discriminatory function, the Glasgow scale, MELD and the Lille’s model. In treatment for Alcoholic Hepatitis, there have been used several drugs whose principal objectives are: to control the inflammatory infiltrated, to block the immunologic process and avoid the progression to fibrosis, this with the finality to increase the survival rate.


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