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ISSN 2992-8036 (Electronic)
ISSN 2306-4102 (Print)
Órgano Oficial del Colegio Mexicano de Ortopedia y Traumatología

2009, Number 6

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Acta Ortop Mex 2009; 23 (6)

Systematic review to assess the effectiveness and safety of parecoxib

Villasís-Keever MA, Rendón-Macías ME, Escamilla-Núñez A

Language: Spanish
References: 34
Page: 342-350
PDF size: 58.50 Kb.


ABSTRACT

Objectives: Conduct a meta-analysis of randomized clinical trials to assess the effectiveness and safety of parecoxib as analgesic for orthopedic surgery. Material and methods: The search strategy included Medline, Embase and Cochrane. Two independent investigators selected the trials. The meta-analyses were performed using the RevMan v.5.0 software. Calculations were based on the similarity of the trials considering the parecoxib dose (20 or 40 mg) and the type of comparator (placebo, other analgesics). Results: A total of 1,253 titles were reviewed and 10 trials that assess parecoxib for hip, knee and spine surgery and bunionectomy were selected. In 6/10 trials parecoxib 40 mg did better in the overall assessment versus the placebo (OR 0.20; 95% CI, 0.13-0.31), in the frequency of rescue analgesic use (OR 0.18; 95% CI, 0.07-0.47) as well as in the use of morphine and in pain intensity at 48 hours (p ‹ 0.001). Three trials did not show any difference between parecoxib and ketorolac, morphine, metamizole or paracetamol. Regarding safety, the frequency of adverse events with parecoxib was similar to the placebo or other analgesics. Conclusions: Parecoxib 40 mg is an effective and safe analgesic choice during the postoperative period in orthopedic surgery.


REFERENCES

  1. Kumar N: Report of a Delphi Study to determine the need for guidelines and to identify the number and topics of guidelines that should be developed by WHO, Geneva, June 2007. www.who.int/medicines/areas/quality_safety/delphi_study_pain_guidelines.pdf: 10-12-2008

  2. Olorunto WA, Galandiuk S: Managing the spectrum of surgical pain: Acute management of the chronic pain patient. J Am Coll Surg 2006; 202: 169-75.

  3. Myles PS: Clinical update: postoperative analgesia. Lancet 2007; 369: 810-2.

  4. Brown AK, Christo PJ, Wu CL: Strategies for postoperative pain management. Best Prac res Clin Anesth 2004; 18: 703-17.

  5. Kehlet H, Wilmore DW: Evidence-based surgical care and the evolution of fast-track surgery. Ann Surgery 2008; 248: 189-98.

  6. Ong CKS, Lirk P, Tan CH, et al: An evidence-based update on nonsteroideal anti-inflammatory drugs. Clin Med Res 2007; 5: 19-34.

  7. Laine L: Approaches to nonsteroideal anti-inflammatory drug use in the high-risk patient. Gastroenterology 2001; 120: 594-606.

  8. Simon LS: Biologic effects of nonsteroideal anti-inflammatory drugs. Curr Opin Rheumatol 1997; 9: 178-82.

  9. Kean WF, Buchanan WW: The use of NSAIDs in rheumatic disorders 2005: a global perspective. Inflammopharmacol 2005; 13: 343-70.

  10. Connolly TP: Cyclooxygenase-2 inhibitors in gynecology practice. Clin Med Res 2003; 1: 105-10.

  11. Lipton RB, Stewart WF, Ryan RE Jr, et al: Efficacy and safety of acetaminophen, aspirin and caffeine in alleviating migraine headache pain three double-blind, randomized, placebo-controlled trials. Arch Neurol 1998; 55: 210-7.

  12. Kehlet H, Dahl JB: The value of multimodal or balanced analgesia in postoperative pain treatment. Anesth Analg 1993; 77: 1048-56.

  13. Kranke P, Morin A, Roewer N: Patients global evaluation of analgesia and safety of injected Parecoxib for postoperative pain: a quantitative systematic review. Anesth Analg 2004; 99: 797-806.

  14. Stichtenoth DO, Frolich JC: The second generation of COX-2 inhibitors: what advantages do the newest offer? Drugs 2003; 63: 33-45.

  15. Offman JJ, MacLean CH, Straus WL, et al: A metaanalysis of severe upper gastrointestinal complications of nonsteroideal anti-inflammatory drugs. J Rheumatol 2002; 29: 804-12.

  16. Deeks JJ, Smith LA, Bradley MD: Efficacy, tolerability and upper gastrointestinal safety of celecoxib for treatment of osteoarthritis and rheumatoid arthritis: systematic review of randomized controlled trials. BMJ 2002: 325: 619.

  17. Coghlan JA, Forbes A, Bell SN, et al: Efficacy and safety of subacromial continuous ropivacaine infusion for pos/operative pain management following arthroscopic rotator cuff surgery: A protocol for randomized double-blind placebo-controlled trial. BMC Muscoloskelet Disord 2008; 9: 56.

  18. Jirarattaanaphochai K, Thienthorg S, Sriraj W, et al: Effect of parecoxib on postoperative pain alter lumbar spine surgery. Spine 2008; 33: 132-9.

  19. Butrón-López FG, Gómez-Blanco LA, Paz-García D, y cols.: Ketorolaco trometamina y parecoxib sódico como coadyuvantes de la anestesia general balanceada: sus efectos sobre los requerimientos transoperatorios de citrato de fentanilo. Rev Mex Anestesiol 2004; 27: 144-51.

  20. Graff J, Arabmotlagh M, Cheung R, Geisslinger G, Harder S: Effects of parecoxib and dipyrone on platelet aggregation in patients undergoing meniscectomy: a double-blind, randomized, parallel-group study. Clin Ther 2007; 29: 438-47.

  21. Rassmussen GL, Steckner K, Hogue C, et al: Intravenous parecoxib sodium for acute pain after orthopedic knee surgery. Am J Orthop 2002; 31: 336-43.

  22. Hubbard RC, Naumann TM, Traylor L, et al: Parecoxib sodium has opioid-sparing effects in patients undergoing total knee arthroplasty under spinal anaesthesia. Br J Anaesth 2003; 90: 166-72.

  23. Malan TP, Marsh G, Hakki SI, et al: Parecoxib sodium, a parenteral cyclooxygenase 2 selective inhibitor, improves morphine analgesia and is opioid-sparing following total hip arthroplasty. Anesthesiology 2003; 98: 950-6.

  24. Koppert W, Frotsch K, Huzurudin N, et al: The effects of paracetamol and parecoxib on kidney function in elderly patients undergoing orthopedic surgery. Anesth Analg 2006; 103: 1170-6.

  25. Martinez V, Belbachir A, Jaber A, et al: The influence of timing of administration on the analgesic efficacy of parecoxib in the orthopedic surgery. Anesth Analg 2007; 104: 1521-7.

  26. Viscusi ER, Gimbel JS, Halder AM, et al: A multiple-day regimen of parecoxib sodium 20 mg twice daily provides pain relief after total hip arthroplasty. Anesth Analg 2008; 107: 652-60.

  27. Grundmann U, Wornle C, Biedler A, et al: The efficacy of the non-opioid analgesic parecoxib, paracetamol and metamizol for postoperative pain relief after lumbar microdisectomy. Anesth Analg 2006; 103: 217-22.

  28. Riest G, Peters J, Weiss M, et al: Preventive effects of perioperative parecoxib on post-disectomony pain. Br J Anaesth 2008; 100: 2456-62.

  29. Desjardins PJ, Traylor L, Hubbard RC: Analgesic efficacy of preoperative parecoxib sodium in an orthopedic pain model. J Am Podiatr Med Assoc 2004; 94: 305-14.

  30. Barden J, Edwards JE, McQuay HJ, et al: Oral valdecoxib and injected parecoxib for acute postoperative pain: a quantitative systematic review. BMC Anesthesiology 2003; 3: 1-9.

  31. Schug SA, Joshi GP, Camu F, et al: Cardiovascular safety of the cyclooxygenase-2 selective inhibitors parecoxib and valdecoxib in the potoperative setting: an analysis of integrated data. Anesth Analg 2009; 108: 299-307.

  32. Amabile CM, Spencer AP. Parecoxib for parenteral analgesia in post-surgical patients. Ann Pharmacother 2004; 38: 882-6.

  33. Tilleul P, Weickmans H, Sean PT, et al: Cost analysis applied to postoperative analgesia regimens: a comparison between parecoxib and proparacetamol. Pharm World Sci 2007; 29: 374-9.

  34. Beaussier M, Weickmans H, Paugam C, et al: A randomized, double-blind comparison between parecoxib sodium and proparacetamol for parenteral postoperative analgesia after inguinal repair in adult patients. Anesth Analg 2005; 100: 1309-15.




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