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2004, Number 1

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Cir Cir 2004; 72 (1)

Cabergoline for inhibition of lactation

Bravo-Topete EG ,Mendoza-Hernández F, Cejudo-Álvarez J, Briones-Garduño C

Language: Spanish
References: 18
Page: 5-9
PDF size: 70.43 Kb.


ABSTRACT

Introduction: Despite advances in prevention inhibition of lactation, only administration of strogens or these combined with androgens show variable effectiveness and are indirectly associated with high percentage for lactation rebound, thrombosis, or pulmonary embolism or both of the later during puerperium; in addition, bromocriptine, also used indirectly for inhibition of lactation, is associated with lactation, rebound in 18-40%. Cabergolin is a new ergoline with efficient and durable prolactin reducer effect with fewer adverse effects.
Problem: Which will the smallest cabergolin dosage be to inhibit lactation?
Objective: To demonstrate clinical effectiveness with smallest cabergolina dosage in lactation inhibition.
Material and methods: We carried on a the Service Clinical test on patients hospitalization with an indication to inhibit lactation as the Hospital of Gynecology and Obstetrics, Infantil Maternal Institute of the State of Mexico (IMIEM). The study was done 80 patients to who we administered oral 0.5 mg cabergoline to 40 patients and another group of 40 whom we administered 1.0 mg of cabergoline orally at random and blinded by means of out-patient consultation. We studied correlation between dose and inhibition of lactation as well as presence of adverse effects.
Results: In the group of patients to whom administered 0.5 mg, we found 65% (n = 26) with lactation inhibition; adverse effects in this group appeared in 32.5% (n = 13) the second group with a dose of 1.0 mg; 95% with adverse effects in 25% P < 0.001.
Conclusions: Inhibition of lactation with unique dose of 1.0 has satisfactory clinical effectiveness, tus being the smaller dose to inhibit lactation at a suitable percentage.


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