2009, Number 4
<< Back Next >>
Ortho-tips 2009; 5 (4)
Implante de condrocitos autólogos en un defecto osteocondral en la articulación del tobillo. Reporte de un caso
Lara-Arias J, Mendoza-Lemus OF, Martínez-Rodríguez H, Álvarez-Lozano E
Language: Spanish
References: 14
Page: 354-360
PDF size: 121.90 Kb.
ABSTRACT
Introduction: In spite of their complex structure, the articular cartilage has a low ability to auto repair. The inclusion of an autologous chondrocytes in three-dimensional matrixes have favoured reparation of osteochondrals injuries in femoral condyls. However, talus injuries constitute a relatively rare pathology of the ankle, and therefore sometimes their treatment is hard.
Methodology: 23 years male patient with history of a full thickness traumatic injury in the talus surface. He was treated with the technique of autologous chondrocytes implant included in fibrin matrix. A second surgery was done after six months to observe the evolution of the defect repairment.
Results: The patient was asymptomatic after four months post-surgery and six months after the implantation. The injury was repaired with the typical characteristics of articular cartilage tissue.
Conclusions: Chondrocytes included in fibrin media can provide a microenvironment for the synthesis of extracellular matrix in lesions of full thickness on the talus surface.
REFERENCES
Brittberg M, Lindahl A, Nillson A, Ohlsson C, Isaksson O, Peterson L. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med 1994; 331: 889-95.
Maracci M, Berruto M, Brocchetta D, Delcogliano A, Ghinelli D, Gobbi A, Kon E, Pederzini L., Rosa D, Sacchetti GL, Stefani G, Zanasi S. Articular cartilage engineering with Hyalograft® C. 3 year clinical results. Clin Orthop Relat Res 2005; 435: 96-105.
Couceiro FJ, Carpintero AP, Silva RMT. Cultivo de condrocitos. Ortop Traumatol 2002; 5: 436-43.
Perka C, Spitzer RS, Lindenhayn K, Sittinger M, Schultz O. Matrix-mixed culture: New methodology for chondrocyte culture and preparation of cartilage transplants. Biomed Mater Res 2000; 49: 305-11.
Tsukasa KMD. Arthroscopic drilling for the treatment of osteochondral lesions of the talus. J Bone Joint Surg 1999; 81-A(9): 1229-34.
Bui M. Osteochondritis dissecans of the tibial plafond: Imaging characteristics and a review of the literature. American J Roentgenology 2000; 175: 1305-9.
Delgado AV, Parrón CR, Tomé F, Rey LA. Resultados del tratamiento de las lesiones osteocondrales del tobillo mediante escisión, curetaje y perforaciones vía artroscópica. Acta Ortop 2005; 6: 18-25.
Barroso-Díaz JL. Resultado del tratamiento de las lesiones osteocondrales de rodilla mediante perforaciones vía artroscópica. Cuadernos de Artroscopia 2004; 11(21): 18-23.
Visna P, Pasa L, Hart R, Kocis J, Cizmar I, Adler J. Treatment of deep chondral defects of the knee using autologous chondrocytes cultured on a support: results after one year. Acta Chir Orthop Traumatol Cech 2003; 70(6): 356-62.
Haisch A, Loch A, David J, Pruss A, Hansen R, Sittinger M. Preparation of a pure autologous biodegradable fibrin matrix for tissue engineering. Med Biol Eng Comput 2000; 38(6): 686-9.
Baums MH, Hedrich G, Schultz W, Steckel H, Kahl E, Klinger HM. Autologous chondrocyte transplantation for treating cartilage defects of the talus. J Bone Joint Surg 2006; 88-A(2): 303-8.
Brittberg M, Peterson L, Sjorgen JE, Tallheden T, Lindhal A. Articular cartilage engineering with autologous chondrocyte transplantation. A review of recent developments. J Bone Joint Surg Am 2003; 85A (3): 109-15.
Sgaglione NA. Biologic approaches to articular cartilage surgery: future trends. Orthop Clin North Am 2005; (4): 485-95.
Mandelbaum BR, Gerhardt MB, Peterson L. Autologous chondrocyte implantation of the talus. Arthroscopy 2003; 19 (10 Suppl 1): 129-37.