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2000, Number 1

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Salud Mental 2000; 23 (1)

El papel de la melatonina como modulador de la organización del citoesqueleto

Benitez-King G

Language: Spanish
References: 46
Page: 18-22
PDF size: 143.09 Kb.


ABSTRACT

Melatonin is a highly lipophilic hormone that crosses the lipid bilayer of cellular membranes. It causes multiple cellular responses in unicellular organisms, plants, and vertebrales. This hormone conveys photoperiodic signals to all organisms and recently it has been describes that it functions as a free radical scavenger.
The mechanisms by which melatonin causes pleiotropic cellular responses have been partially disclosed: Melatonin binds to plasma membranal receptors coupled to both adenylate cyclase and phospholipase C pathways. It also binds to orphan nuclear receptors of the retinoid family. Moreover, melatonin binds and modulates the activity of two intracellular proteins calmodulin and protein kinase C. This mechanism is related to ancient physiological processes phylogenetically well preservad, such as cytoskeletal rearrangements. In this paper I review the evidence supporting that melatonin modulates the organization of the three main cytoskeletal components: microtubules, microfilaments and intermediate filaments. Also, the current knowledge about the mechanisms by which the hormone modulates cytoskeleton organization and its possible physiological consequences are presented.


REFERENCES

  1. ANDO SK, TANABEK Y, GONDA C, SATO M: Inagaki. Domain and sequence specific phosphorylation of vimentin induced disassembly of the filament structure. Biochemistry, 28:2974-2979, 1989.

  2. ANTON-TAY F, CHOU C, ANTON S, WURTMAN RJ: Brain serotonin concentration: Elevation following intraperitoneal administration of melatonin. Science, 162:277-278, 1968.

  3. ANTON-TAY F, RAMIREZ I, MARTINEZ G, BENITEZKING G: In vitro stimulation of protein kinase C by melatonin. Neurochem Res, 23:605-610, 1998.

  4. BANERJEE S, KEER V, WINSTON M, KELLEHER KJ, MARGULIS L: Melatonin inhibitor of microtubule based oral morphogenesis. In Stentor Coeruleus. J Protoozol, 19:108-113, 1972.

  5. BANERJEE S, MARGULIS L: Mitotic arrest by melatonin. Exp Cell Res, 78:314-318, 1973.

  6. BENITEZ-KING G: PKC activation by melatonin modulates vimentin intermediate filament organization in N1E-115 cells. J Pineal Res, 1999 (en prensa).

  7. BENITEZ-KING G, ANTON-TAY F: Calmodulin mediates melatonin cytoskeletal effects. Experientia, 49:635-641, 1993.

  8. BENITEZ-KING G, ANTON-TAY F: The role of melatonin in cytoskeletal remodeling is mediated by calmodulin and protein kinase C. Front Horm Res, 21:154-159, 1996.

  9. BENITEZ-KING G, ANTON-TAY E: Calmodulin and protein kinase C α are two Ca++ binding proteins that mediate intracellular melatonin signaling. En: Pineal Gland Update: 1996 From Molecular Mechanisms to Clinical Implications. Webb SM, Puig-Domingo M, Moller M, Pevet P, (eds). PJD Publications Limited, 13-20, Nueva York, 1997.

  10. BENITEZ-KING G, RAMIREZ G: Protein C/calmodulin: An intracellular signaling system involved in actin. Microfilament rearrangements elicited by melatonin. Neuro Immuno Modulation, 6:448, 1999.

  11. BENITEZ-KING G, HUERTO-DELGADILLO L, ANTONTAY F: Melatonin effects on the cytoskeletal organization of MDCK and neuroblastoma N1E-115 cells. J Pineal Res, 9:209-220, 1990.

  12. BENITEZ-KING G, HUERTO-DELGADILLO L, ANTONTAYF: Binding of 3H-Melatonin to calmodulin. Life Sci, 53:201-207, 1993.

  13. BERKOWITZ SA, WOLFF J: Intrinsic calcium sensitivity of tubulin polymerization. J Biol Chem, 256:11216-11223, 1981.

  14. BERSHADSKY AD, VASILEV JM: En: Cytoskeleton, Plenum Press, Nueva York, 1988.

  15. CARDINALI DP, NAGLE CA, FREIRE F, ROSNER JM: Effects of melatonin on neurotransmitter uptake and release by synaptosome-rich homogenates of the rat hypothalamus. Neuroendocrinology, 18:72-85, 1975.

  16. CARDINALI DP, FREIRE F: Melatonin effects on brain. Interaction with microtubule protein, inhibition of fast axoplasmic flow and induction of crystaloid and tubular formation in the hypothalamus. Mol Cell Endocrinol, 2:317-330, 1975.

  17. CARDINALI DP: Molecular biology of melatonin: Assessment of the “microtubular hypothesis of melatonin action”. En: Melatonin Current Status and Perspectives. Birau N, Schloot W, (eds), 247-256, Pergamon Press, Nueva York, 1981.

  18. CARLBERG C, WIESSENBERG I: The orphan receptor family RZR/ROR melatonin and 5-lipoxygenase: An unexpected relationship. J Pineal Res, 18:171-178, 1995.

  19. CEREIJIDO M, ROBBINS ES, DOLAN WJ, ROTUNNO CA, SABATINI DD: Polarized monolayers formed by epithelial cells on a permeable and translucent support. J Cell Biol, 77:853-880, 1978.

  20. DUBOCOVICH ML: Melatonin a potent modulator of dopamine release in the retina. Nature, 306:782-784, 1983.

  21. DUBOCOVICH ML: Melatonin receptors: are there multiple subtypes. Tips, 16:50-56, 1995.

  22. FITZGERALD TJ, VEAL A: Melatonin antagonizes colchicine induced mitotic arrest. Experientia, 32:372-373, 1976.

  23. FREIRE F, CARDINALI DP: Effects of melatonin treatment and environmental lighting on the ultrastructural appearance, melatonin sintesis norepinephrine turnover and microtubule protein content of the rat pineal gland. J Neural Trans, 37:237-257, 1975.

  24. GLENNY JR, WEBER K: Calmodulin-binding proteins of the microfilaments present in isolated brush borders and microvilli of intestinal epithelial cells. J Biol Chem, 255:10551-10554, 1980.

  25. GRATZER WB, BAINES AJ: Calmodulin and cytoskeletal function. En: Molecular Aspects of Cellular Regulation: Calmodulin. Cohen P, Klee JCB (eds). Elsevier, Amsterdam, Nueva York, Oxford, 5:357-364, 1988.

  26. HARDELAND R, BALZER I, POEGGELER B, FUHRBERG B, URIA H, BEHMANN G, WOLF R, MEYER TJ, REITER RJ: On the primary functions of melatonin in evolution: Mediation of photoperiodic signals in a unicell, photooxidation, and scavenging of free radicals. J Pineal Res, 18:104-111, 1995.

  27. HUERTO-DELGADILLO L, ANTON-TAY F, BENITEZKING G: Effects of melatonin on microtubule assembly depend on hormone concentration: Role of melatonin as a calmodulin antagonist. J Pineal Res, 17:55-62, 1994.

  28. JACKSON WT: Regulation of mitosis II. Interaction of isopropyl N-phenyl-carbamate and melatonin. J Cell Sci, 5:745-755, 1969.

  29. JULIEN JP, MUSHYNSKY WE: Neurofilaments in health and disease. Prog Nucleic Acid Res Mol Biol, 61:1-23, 1998

  30. KOPIN IJ, PARE CM, AXELROD J, WEISSBACH H: The fate of melatonin in animals. J Biol Chem, 236:3027-3075, 1961.

  31. KUMAGAI HE, NISHIDA E, KOTANI S, SAKAI H: On the mechanism of calmodulin-induced inhibition of microtubule assembly in vitro. J Biochem, 99:521-525, 1986.

  32. MALAWISTA SE: The effects of colchicine and cytochalasin B on the hormone-induced movement of melanin granules in frog dermal melanocytes. En: Endocrinology. Scow RO, Ebling FJG, Henderson IW (eds), Excerpta, Amsterdam, 288, 1973.

  33. McARTHUR A, HUNT A, GILLETE M: Melatonin action and signal transductionin the rat suprachiasmatic circadian clock: activation of protein kinase C at dusk and dawn. Endocrinology, 138:627-634, 1997.

  34. MEZA I, IBARRA G, SABANERO M, MARTINEZ-PALOMO A, CEREIJIDO M: Occluding junctions and cytoskeletal components in a cultured transporting epithelium. J Cell Biol, 87:746-754, 1980.

  35. MITCHELL CK, REDBURN DA: Melatonin inhibits Ach release from rabbit retina. Visual Neurosci, 7:479-486, 1991.

  36. MURTI KG, KAUR K, GOORHA RM: Protein kinase C associates with intermediate filaments and stress fibers. Exp Cell Res, 202:36-44, 1992.

  37. PANG SF, YEW DT: Pigment aggregation by melatonin in the retinal pigment epithelium and choroid of guinea-pigs, Cavia porcellus. Experientia, 35:231-233, 1978.

  38. PERRINO BA, CHOU IN: Calmodulin modulation of adverse effects of Cd2+ on microtubules and tubulin polymerization in vitro. In vitro, 3: 227-234, 1989.

  39. RATUSHNYAK AS, ZAPARA TA, ZHARKIKH AA, RATUSHNYAK OA: Effects of changes in dinamic equilibrium in microtubule and microfilament system on the plastic responses of neurons. Neurosci Behav Physiol, 27(4):353-359, 1997.

  40. REITER RJ: Pineal melatonin: Cell biology of its synthesis and of its physiological interactions. Endocr Rev, 12:151-180, 1991.

  41. REITER RJ, POEGGELER B, TAN DX, CHEN LD, MANCHESTER LC, GUERRERO JM: Antioxidant capacity of melatonin: A novel action not requiring a receptor. Neuroendocrinol Letts, 15:103-116, 1993.

  42. REPPERT SM, WEAVER DR, EBISAWA T: Cloning and characterization of a mammalian receptor that mediates reproductive and circadian responses. Neuron, 13:1177-1185, 1994 .

  43. ROMERO MP, GARCIA-PERGAÑEDA A, GUERRERO JM, OSUNA C: Membrane-bound calmodulin in Xenopus laevis oocytes as a novel binding site for melatonin. FASEB J, 12:1401-1408, 1998.

  44. SCHWARTZ JH: Axonal transporte components, mechanisms, and specificity. Annu Rev Neurosci, 2:467-504, 1979.

  45. SHELANSKI ML, GASKIN F, CANTOR R: Microtubule assembly in the absence of added nucleotides. Proc Natl Acad Sci USA, 70:765-768, 1973.

  46. TRIFARO J-M, VITALE ML: Cytoskeleton dinamics during neurotransmitter release. Elsevier Science Publishers Ltd. TINS, 16:466-472, 1993.




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