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ISSN 1665-3254 (Print)
Revista Oficial de la Universidad Biomédica Rafael Guízar y Valencia A. C.

2008, Number 1-2

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Plasticidad y Restauración Neurológica 2008; 7 (1-2)

Evaluation of neurological restoration in patient with Ataxy SCA2 Cuban experience

Rodríguez DJC, Velázquez PCL, Sánchez CG, Almaguer ML, Almaguer GD, García FJC, Rodríguez LR, Soto GHO

Language: Spanish
References: 31
Page: 13-18
PDF size: 110.27 Kb.


ABSTRACT

The Hereditary Ataxias represents a problem of health in Cuba, specifically in the province of Holguín where it concentrates more of 80% of the patients and relatives in risk. The 73% of the patients and 76% of the relatives are in risk that lives in Cuba.
Belong to the spinocerebellous Ataxia Type 2 (SCA2, of the English Spinocerebellar Ataxia Type 2) SCA2 this Ataxia characterizes by a cerebellous syndrome with predominance of the upheavals of the coordination, the saccadic movements of the eyes, instability of walking, speech and ocular movements disorders, as well as an early peripheral neuropathy. The programs of rehabilitation focused to the motor, visual were made and cardiac too. This study includes 96 patients. The DNA he was isolated of with the «DNA Isolation kit» (Puregene - Gentra Systems) from leukocytes of peripheral blood. The reaction chain of polymerase (PCR), the amplification of the region with segment (CAG) was made in gene SCA2. The statistical results were Student´s t, analysis of the variance, in twin samples made to patients with SCA2 before and after the physical-motor rehabilitation, showed to statistically significant differences for the Integral variable of the maneuver of saccadic movements and dysdiadococinetic. The percentage of the subjects with smaller values is significant in relation to evaluation before and after. The results were observed or equal increase 10.05 and one diminution of these for values superior to 47.54 after the rehabilitation therapy. The improvement experienced from the clinical point of view by the rehabilitated patients could be related to the function of the cerebellum in the motor learning, since it has been demonstrated in previous works. This can be associated with phenomena of neuroplasticity at cerebellum level.


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