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Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán

2000, Number 4

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Rev Biomed 2000; 11 (4)

The role of the cytokines in the pathogenesis of cytomegalovirus-associated disease

Villalba-Magdaleno JD, Valdés-Espinosa RA

Language: Spanish
References: 26
Page: 293-300
PDF size: 43.28 Kb.


ABSTRACT

Human cytomegalovirus (HCMV) infection is an important cause of morbidity and mortality in immunocompromised patient such as AIDS patients and organ transplant recipients. HCMV disease commonly results from the reactivation of a latent infection, causes various inflammatory diseases such as encephalitis, interstitial pneumonitis, retinitis, hepatitis, gastritis and colitis. The results of experiments from the mouse model and infected human suggested that the cytokines, such as IFN-γ, TNF-α, IL-6, IL-8, and cytokineinduced nitric oxide mediate the pathogenesis of cytomegalovirus-associated disease. However, the how and why the HCMV infection enhancers the production of the cytokines is still unknown. The relation between increased cytokine plasma levels and the appearance of HCMV antigens suggests that cytokines may play an important role in the immunopathological complications. The inhibition of the release or action of those cytokines may be an alternative strategy for preventing HCMV associated morbidity in immunocompromized patients.


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