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Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán

2000, Number 1

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Rev Biomed 2000; 11 (1)

The importance of the long repeated terminal sequence (LTR) in the pathogeny of the human immunodeficeincy virus

Gómez-Román R, Soler-Claudín C

Language: Spanish
References: 55
Page: 61-71
PDF size: 54.33 Kb.


ABSTRACT

The Long Terminal Repeat (LTR) of the human immunodeficiency virus genome functions as an essential site for the control of viral transcription. Although the LTR does not codify either structural or accessory proteins, its function is intimately linked to viral replication in response to mitogens, citokines and even other stimuli generated by opportunistic infectious agents. This revision attempts to describe the in vitro function of the LTR in viral replication and its importance in the pathogenesis of the acquired immunodeficiency syndrome.


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