Aké-López JR, Quintal-Franco JA, Segura-Correa JC

Language: Spanish
References: 34
Page: 100-108
PDF size: 36.32 Kb.

ABSTRACT

Introduction. Gestation rate after embryo transfer can be affected by handling performed during transferring procedures, which negatively influences embryo development. Such a situation interferes with an adequate maternal recognition of pregnancy which results in luteolysis and embryo losses. One alternative to improve gestation rate in embryo recipient females is by lengthening corpus luteum lifespan. The latter can be achieved through treatment with drugs that inhibit synthesis and secretion of prostaglandin F2 a to block luteolysis.
Objective. The aim of this study was to evaluate the effect of Flunixin Meglumine(FM) on the duration of luteal phase, gestation rate, and prolificacy of embryo receptor ewes.
Materials and Methods. Twenty ewes were used as recipients and upon embryo transfer were assigned to one of two treatments: FM2 ewes (n = 10) were treated twice daily (06:00 and 18:00 h) with 2.2 mg/kg of Flunixin Meglumine (Fynadine, Schering Plough); Controls (n=10 ewes) which received a vehicle injection once daily (06:00 h). Both groups were treated for 8 days, starting on day 5 after embryo transfer. Blood samples were taken daily in order to quantify circulating concentrations of progesterone from day 15 to 19 after estrus.
Results. Gestation rate of Control group was 50% and FM2 was 40% (p›0.05). Prolificacy was similar (p›0.05) between Controls and FM2 ((1.4 vs. 1.25 lambs/ewe respectively). Length of luteal phase was greater in ewes of the FM2 group than in the Controls (18.1 vs. 16.2 days respectively; p‹0.05)
Conclusion. Treatment with Flunixin Meglumine (2.2 mg/kg) twice daily had no effect on gestation rate and prolificacy of embryo recipient ewes, even though it delayed luteolysis.

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