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2009, Number 1

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Rev Inst Nal Enf Resp Mex 2009; 22 (1)

Biogenesis of mycobacterial phagolysosome and its role in antigen processing and presentation

Bobadilla-Lozoya K, Rivas-Santiago B, Sada-Díaz E, Torres-Rojas M

Language: Spanish
References: 52
Page: 56-62
PDF size: 78.18 Kb.


ABSTRACT

Mycobacterium tuberculosis (M.tb) is an intracellular pathogen that survives within host macrophages. M.tb is phagocytosed by receptors on the cell membrane such as the CR1 complement receptor, mannose receptor, fibrin receptor, etc. Once M.tb is phagocytosed, a rearrangement of membranes occurs to form the phagosome. The phagosome is an intracellular organelle where M.tb survives and where mycobacterial proteins are processed to bind to MHC class II proteins in endosomal compartments, so they can be presented at the cell membrane and activate CD4+ T cells. It has been recently described that phagosome is not just the site of antigen degradation; it is also a competent organelle where peptide-MHC-II complexes are formed. Experimental evidences have shown that live M.tb decreases formation of these complexes in the phagosome, but the exact mechanism that determines the site of formation of the peptide-MHC-II complexes and its biological implications are unknown.


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