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2009, Número 1

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Rev Inst Nal Enf Resp Mex 2009; 22 (1)


Biogénesis del fagolisosoma micobacteriano y su papel en el procesamiento y presentación del antígeno

Bobadilla-Lozoya K, Rivas-Santiago B, Sada-Díaz E, Torres-Rojas M

Idioma: Español
Referencias bibliográficas: 52
Paginas: 56-62
Archivo PDF: 78.18 Kb.


RESUMEN

Mycobacterium tuberculosis (M.tb) es un patógeno intracelular que logra sobrevivir en los macrófagos del huésped. M.tb es fagocitado mediante receptores de la membrana celular, como los receptores del complemento 1 (CR1), de manosa, de fibrina, etc. Una vez que M.tb es fagocitado se inicia un reordenamiento de membranas para formar el fagosoma, el organelo intracelular donde M.tb sobrevive y donde proteínas micobacterianas son procesadas para unirse a las proteínas de MHC clase II en los compartimentos endosomales, y ser presentadas a nivel de la membrana celular y activar a las células T CD4+. Recientemente se ha descrito que el fagosoma no es sólo el sitio de degradación de antígenos, sino que es también un organelo competente donde los complejos péptidos-MHC-II se forman. Evidencias experimentales han mostrado que M.tb viva disminuye la formación de estos complejos en el fagosoma, pero se desconocen los mecanismos que determinan el sitio de formación de los complejos péptidos-MHC-II y sus implicaciones biológicas.


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