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2005, Number 3

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Rev Odont Mex 2005; 9 (3)

Oral premedication with midazolam and ketamine, in pediatric patients before surgical treatment. Comparative study

Chávez NEJ, Cortés OE, Hinojosa AA, Araiza TMÁ

Language: Spanish
References: 34
Page: 131-136
PDF size: 175.04 Kb.


ABSTRACT

The oral premedication in children prior to maxillofacial surgery is a good alternative. The objective of this study was to compare the preanesthetic effect of midazolam and ketamine in pediatric patients before surgical procedures. Twenty four patients, 14 boys and 10 girls, aged between 8 months to 14 years old, were randomly selected and grouped into two groups. Patients of group one took 0.75 mg/kg of midazolam, thirty minutes before the surgical procedure was done. Group 2 took 6.0 mg/kg of ketamine. In both cases drugs were diluted in 5 mL of apple juice. Twenty minutes after drugs were administrated, the following conditions were observed: 1) response to drug 2) response to the family separation circumstance and the entrance to the operating room, 3) response to the venous injection. Statistic comparisons, were done using Mann-Whitney. In response to drug, we could not established a statistically significant difference (p = 0.977). Data obtained upon the separation of parents and immediate response after entering the operating room, as well as that observed at the moment of the venous injection was not statistically different in both groups (p = 0.79). Preanesthetic effect using midazolam or ketamine (oral route), showed the same results in pediatric patients surgically treated.


REFERENCES

  1. Hernández M, Trejo J. Premedicación por vía oral en niños: ketamina vs midazolam en jugo de manzana. Anest Mex 1999; 11(1): 5-8.

  2. Viitanen H, Annila P. Premedication with midazolam delays recovery after ambulatory sevoflurane anesthesia in children. Anesth Analg 1999; 89(1): 75-79.

  3. Eidelman EF. A comparison of restorations for children with early childhood caries treated under general anesthesia or conscious sedation. Pediatric Dentistry 2000; 22(1): 33-38.

  4. Peretz BE. Dental health of children and strategies for prevention. In: Community dental health. United States of America. Ed. Mosby. 1998.

  5. Pinkham J, Casamassimo P. Odontología Pediátrica. 2ª Ed. México. Ed Interamericana. 1996.

  6. Nelson W, Behrman R, Arvin A. Tratado de Pediatría. 15a Ed. México. Ed Mc Graw-Hill- Interamericana. 1997.

  7. Figuereido L, Ferelle A. Odontología para el bebé. Colombia. Ed. Actualidades Médico Odontológicas Interamericanas. 2000.

  8. 8. Vickers, Wood-S. Fármacos en la anestesia. México. Ed. Salvat. 1981.

  9. Wilson S, Farrell K. Conscious sedation experiences in graduate pediatric dentistry programs. Pediatric Dentistry 2000; 23: 307-314.

  10. Nathan J, Vargas K. Oral midazolam with and without meperidine for management of the difficult young pediatric dental patient: a retrospective study. Pediatric Dentistry 2002; 24(2): 129-134.

  11. Brosius K, Bannister F. Oral midazolam premedication in preadolescents and adolescents. Anesthesia and Analgesia 2002; 94: 31-36.

  12. Bermudez L, Serrano C. Comparación entre ketamina oral vs clonidina oral como premedicación en niños. Anest Mex 1994; 5: 282-286.

  13. Kupietzky A, Blumenstyk A. Comparing the behavior of children treated using general anesthesia with dose treated using conscious sedation. J Dent Child 1998; 65: 122-127.

  14. Paladino MA, Rojas J. Drogas conocidas en nuevas formas farmacéuticas: Midazolam jarabe. Rev Arg Anest 2001; 59(1): 27-31.

  15. Sullivan D, Wilson C. A comparison of two oral ketamine-diazepam regimens for the sedation of anxious pediatric dental patients. Pediatric Dentistry 2001; 23(3): 223-230.

  16. American Academy of Pediatric Dentistry: Guidelines for the elective use of pharmacologic conscious sedation and deep sedation in pediatric dental patients. Pediatric Dentistry 1996; 6: 7-11.

  17. Weldon B. Oral midazolam in children; effect of time and adjuntive therapy. Anesth Analg 1992; 75: 51-55.

  18. Nicolson S. Comparison of oral and intramuscular preanesthesic medication for pediatric in patient surgery. Anesthesiology 1989; 71: 8-10.

  19. Payne K. The pharmacokinetics of midazolam in pediatric patients. Eur J Clin Pharmacol 1989; 37: 267-272.

  20. Horgesheimer J, Pribble C. The effect of midazolam premedication on discharge time in pediatric patients undergoing general anesthesia for dental restorations. Pediatric Dentistry 2001; 23(6): 491-494.

  21. Billard V, Gambus P. A comparison of spectral edge, delta power, and bispectral index as EEG measures of alfentanil, propofol, and midazolam drug effect. Clinical and pharmacology and therapeutics 1997; 61: 58.

  22. Vidal M. Premedicación oral en niños: una comparación de dos dosificaciones de midazolam en cirugía ambulatoria. Rev Mex Anest 1994; 17: 177-182.

  23. Virtue R. An anesthetic: 2- ortochlorophenyl, 2 methylaminocy-clohexanone HCL. Anesthesiology 1967; 28: 823-833.

  24. Reboso J, González F. Ketamina. Rev Esp Anestesiol Reanim 1999; 46(3): 29-38.

  25. Brzustowicz R. Efficacy of oral premedication for pediatric outpatient surgery. Anesthesiology 1984; 60: 475-477.

  26. Howard B. Oral ketamine preanesthetic medication in children. Anesthesiology 1992; 76: 28-33.

  27. Rosen D. A palatable Gelatin vehicle for midazolam and ketamine. Anesthesiology 1991; 75: 914.

  28. Bosques N. Medicación preanestésica por vía oral con midazolam disuelto en chocolate en pacientes pediátricos sometidos a cirugía ambulatoria. Rev Mex Anest 1992; 15: 171-175.

  29. Vademecum Farmacéutico. 9a edición. México. Ed Mc Graw Hill Interamericana. 2000.

  30. Yaster M, Krane E. Pediatric pain management and sedation handbook. United States of America. Edit Mosby. 1997.

  31. Bosques G, Romero P. Medicación preanestésica por vía oral con midazolam y ketamina en jugo de manzana, para pacientes sometidos a cirugía ambulatoria. Rev Mex Anest 1996; 19: 61-64.

  32. Davis P. Preanesthetic Medication with intranasal for brief pediatric surgical procedures. Anesthesiology 1995; 82: 2-5.

  33. Milnes A, Paed D. Intravenous sedation in pediatric dentistry using midazolam, nalbuphine and doperidol. Pediatric Dentistry 2000; 22(2): 113-119.

  34. Cioca R. Oral transmucosal ketamine and effective premedication in children pediatric. Anesthesiology 1996; 6(5): 361-365.




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