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2008, Number 6

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Gac Med Mex 2008; 144 (6)

Efecto del ibuprofeno y ácido acetilsalicílico sobre el deterioro cognitivo, poder antioxidante total e isoprostanos séricos

Ibáñez-Hernández MG, Macías-Islas MA, Zavalza-Gómez AB, Pacheco-Moisés FP , Ortiz GG

Language: Spanish
References: 37
Page: 497-502
PDF size: 77.62 Kb.


ABSTRACT

Background: There is controversy about the prevention of Alzheimer’s disease with nonsteroidal antiinflammatory drugs (NSAIDs). Our objective was to evaluate the effect of ibuprofen and acetylsalicylic acid on cognitive impairment, serum total antioxidant power (TAP) and isoprostane (8-iso-PGF2á). Methods: We applied from April 2004 to February 2006 a Folstein mini-mental state (MMSE), Syndrome Kurtz Test (SKT) and a geriatric depression scale (Yasevage) to eighteen eligible women. They were 55 years and older. All women (n=18) with normal cognitive state were randomized to ibuprofen 400 mg per day (n=9) and acetylsalicylic acid 500 mg per day (n=9) for one year. Serum TAP and 8-iso-PGF2á were performed at baseline, after six months and one year of treatment. Results: After one year of treatment with acetylsalicylic acid five women (55.6%) raised their score 4 points in MMSE compared with 3 points increased (33.3%) showed by the ibuprofen group. TAP increased (p=0.01) and 8-iso-PGF2á reduced (p=0.01) in both groups compared with baseline. Conclusions: Both drugs improved the cognitive state and oxidative status of our population.


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