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Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán

2004, Number 2

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Rev Biomed 2004; 15 (2)

Lymphocyte receptors in the innate immune response

Cocom-Góngora PC, Mut-Martín MC, García-Miss MR

Language: Spanish
References: 64
Page: 113-122
PDF size: 47.68 Kb.


ABSTRACT

Natural killer lymphocytes (NK) are cells of the innate immune response and the identification of their receptors has contributed to the understanding of their reactivity and specificity. These lymphocytes become activated by the recognition of the non-self cells or altered own cells through their activating receptors such as CD16, CD2, CD28, and CD161. Consequently, cells expressing altered MHC class I molecules become susceptible to NK cell-mediated attack by linking of their activating receptors. Cytotoxic activity the NK cells is regulated by their inhibitory receptors which recognize molecules of MHC class I, and such recognition prevents the destruction of own normal cells. Among the inhibitory receptors are KIR, Ly49, CD94/NKG2, and KLRE1. Most of these receptors are molecules of the Ig or the C-type lectin superfamilies. Here the characteristics of several activating and inhibitory NK cell receptors are reviewed, and their heterogenecity and role in the control of the immune response are discussed.


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