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Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán

2004, Number 1

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Rev Biomed 2004; 15 (1)

Transactivation of tyrosine kinase receptors (RTK’s) by G protein-coupled receptors (GPCR’s)

Sánchez-Lemus E, Arias-Montaño JA

Language: Spanish
References: 66
Page: 33-48
PDF size: 3939.42 Kb.


ABSTRACT

The effects of growth factors and those of some hormones are mediated by the activation of receptors with an intrinsic activity of tyrosine kinase (receptor tyrosine kinases, RTK’s); whose stimulation triggers signalling cascades that regulate transcriptional events crucial for cell growth and differentiation. Among the effects that follow RTK stimulation, the activation of the family of mitogen-activated protein kinases (MAPK´s) bears particular relevance.
There is evidence that the stimulation of several G protein-coupled receptors (GPCR’s) results in RTK activation in the absence of ligands for the latter. This phenomenon is known as transactivation, and relies on intracellular signals induced by GPCR stimulation, in which both the a subunit and the bg complexes of the corresponding G proteins, as well as phosphorylation processes mediated by different kinases are involved. Herein we review the mechanisms responsible for the activation of GPCR’s and RTK’s, as well as the characteristics of RTK transactivation by GPCR’s.


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