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Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán

2004, Número 1

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Rev Biomed 2004; 15 (1)


Transactivación de receptores con actividad de cinasa de tirosina (RTK’s) por receptores acoplados a proteínas G

Sánchez-Lemus E, Arias-Montaño JA

Idioma: Español
Referencias bibliográficas: 66
Paginas: 33-48
Archivo PDF: 3939.42 Kb.


RESUMEN

Los efectos de los factores de crecimiento y de ciertas hormonas se deben a la activación de receptores con actividad intrínseca de cinasa de tirosina (o RTK’s, por receptor tyrosine kinases), cuya estimulación inicia cascadas de señalización intracelular que regulan eventos transcripcionales esenciales para la proliferación y la diferenciación celulares. Entre los efectos debidos a la estimulación de los RTK’s, destaca la activación de la familia de cinasas de proteína activadas por mitógeno o MAPK’s (mitogen-activated protein kinases).
Existen evidencias que indican que la estimulación de algunos receptores acoplados a proteínas G (o GPCR’s, por G protein-coupled receptors) resulta en la activación de RTK’s en ausencia de un ligando para estos últimos. Este proceso ha sido denominado transactivación, y depende de señales intracelulares inducidas por la estimulación de GPCR’s en las que participan tanto las subunidades a como los complejos bg de las proteínas G, así como fenómenos de fosforilación mediados por diferentes cinasas. En este artículo se revisan las características estructurales de ambos tipos de receptores (GPCR’s y RTK’s), los mecanismos responsables de su activación y los procesos involucrados en el fenómeno de transactivación de RTK’s por activación de GPCR’s.


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