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Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán

2007, Number 1

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Rev Biomed 2007; 18 (1)

Abdominal angiostrongyliasis: notes on its diagnosis

Abrahams-Sandí E

Language: Spanish
References: 37
Page: 37-45
PDF size: 261.43 Kb.


ABSTRACT

Abdominal angiostrongyliasis, caused by Angiostrongylus costaricensis, is a clinical entity characterized by abdominal pain usually located in the right iliac fossa, accompanied, in some cases, by a tumor-like mass, painful to palpation, which may be confused with a malignancy. Due to the lack of specificity of the symptoms, this parasitosis may also often be confused with an acute abdomen. While in countries like Brazil and Costa Rica the reported incidence reaches up to 28% and 600 cases per year, respectively, the real prevalence and incidence of this parasitosis in the rest of Latin America is unknown, and for some countries it continues to be a rare disease. Since coproparasitological confirmation is not possible for the diagnosis of the infection in humans, an alternative tool has been the development of immunologic techniques for the detection of antibodies in the serum of infected patients. Further, the usefulness of different antigens for an immunological diagnosis has been evaluated using techniques such as ELISA, Western Blot, and immunofluorescence. Among the antigens tested are crude somatic extracts of larval and adult forms, excretion secretion antigens, low molecular weight fractions, and, most recently, egg antigens. In the field of molecular biology, the development of primers that allow the detection of parasite DNA in the serum of suspected patients have also been reported.
This review compiles and analyzes the results of these studies, and emphasizes the need to continue working in the development of a diagnostic test that can elucidate the real impact of abdominal angiostrongyliasis on public health in Latin America.


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