2009, Number 1
Intramyocardial injection «sowing» technique for cellular therapy in terminal cardiac insufficiency. Original procedure
Language: Spanish
References: 12
Page: 5-9
PDF size: 125.57 Kb.
ABSTRACT
Introduction: Within the surgical procedures for treatment of terminal heart failure, cell transplantation can be used individually or in combination with surgical procedures such as myocardial revascularization. Implantation techniques, however, have given rise to controversy, which is the reason why we decided to determine the degree of inclusion of a contrast medium applied to the myocardium. Materials and methods: This was an experimental study using adult pig hearts, distributed randomly into two groups, with two subgroups each. Group I (n = 6): pig hearts injected with a contrast medium through a simultaneous application with multiple syringes («sowing» pattern) Group II (n = 6): pig hearts injected with an intramyocardial contrast medium with an only syringe. The hearts were subjected to a radiological study to compare the distribution of the contrast medium. Fisher’s exact test was utilized for the comparison between both groups. The value of p to consider the differences as significant was set below 0.05. Results: A more homogenous distribution of the contrast medium was observed in the radiographies taken after the corresponding injections to Group I than in those taken for Group II, with a value for p = 0.002. Conclusion: The «sowing» injection technique is the procedure of choice for this type of patients.REFERENCES
Kessinger A, Smith DM, Strandjoud SE, Landmark JD, Dooley DC, Law P, Coccia PF, Warkentin PI, Weisenburger DD, Armitage JO. Allogeneic transplantation of blood-derived, T cell-depleted hemopoietic stem cells after myeloablative treatment in a patient with acute lymphoblastic leukemia. Bone Marrow Transplant 1989; 4: 643-646.
Hyun-Jae K, Hyo-Soo K, Shu-Ying Z, Kyung-Woo et al. Effects of intracoronary infusion of peripheral blood stem-cell mobilized with granulocyte-colony stimulating factor on left ventricular systolic function and restenosis after coronary stenting in myocardial infarction: The MAGIC CELL randomized clinical trial. Lancet 2004; 363: 751-756.