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ISSN 2007-1752 (Print)
Archivos de Medicina de Urgencia de México

2009, Number 1

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Arch Med Urg Mex 2009; 1 (1)

Correlation between lactate seric level and oxigen central venous saturation as perfusion markers in severe sepsis and septic shock

Acuña-Nieto O, Russi-Hernández M, Esquivel-Chávez A

Language: Spanish
References: 20
Page: 12-17
PDF size: 161.75 Kb.


ABSTRACT

Objective: The serum lactate was used as an indicator of tissue perfusion in patients with sepsis, severe sepsis and septic shock. Monitoring of central venous oxygen saturation (ScvO2) is also used as an indirect marker of tissue perfusion. The purpose of our study was to evaluate the correlation of lactate and ScvO2 and comparing the secondary form bicarbonate (HCO3), blood pH and base deficit (BEefc). Methods: Cross-sectional study, 20 patients with non-experimental (11 males and 9 females) with sepsis, severe sepsis and septic shock. Blood samples were obtained from central venous catheter, at the time of diagnosis of which were obtained the values of the lactate as ScvO2 simultaneously. Results: According to data obtained no correlation was present between the ScvO2 and lactate (r = 0.01037, 95% CI -0.43 to 0.45, p = 0.9654). A positive correlation between ScvO2 and blood pH (r = 0.5301, 95% CI 0.11 to 0.78, p = 0.05). Of the samples tested were found more elevated levels of lactate in patients with septic shock than in patients with severe sepsis. Conclusions: There is no correlation between lactate and ScvO2. ScvO2 therefore can not be taken as direct indicator of tissue perfusion in states of sepsis, severe sepsis and septic shock.


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