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ISSN 0187-5337 (Print)
Instituto Nacional de Perinatología

2008, Number 4

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Perinatol Reprod Hum 2008; 22 (4)

Efecto del consumo de una dieta rica en vitaminas C y E sobre marcadores de estrés oxidativo periférico en mujeres con endometriosis

Mier CJ, Aburto ST, Muñoz TX, Aguayo GP, García LE, Hernandez GC

Language: Spanish
References: 42
Page: 250-260
PDF size: 473.57 Kb.


ABSTRACT

Objective: To evaluate the effectiveness in diminishing peripheral oxidative stress markers by means of the design and application of a high-in vitamins C and E diet.
Methods: The study included infetile women with laparoscopic diagnosis of endometriosis from the Instituto Nacional de Perinatologia “Isidro Espinosa de los Reyes”. Two groups were created and women with endometriosis were randomly allocated to the control gropup (n = 15), which received a normal diet, or the vitamins group (n = 15), which received a high-in vitamins C and E diet. All the patients assisted to 5 follow-up visits and received nutritional council. In each visit, periopheral blood samples were taken to determine lipid hidroperoxides (LHP) and malondialdehyde (MDA) concentrations.
Results: The high-in vitamins C and E diet designed and given to the vitamins group had 660% Recommended Dietary Intake (RDI) pf votamin C (500 mg of ascorbic acid) and 133% RDI of vitamin E (20 mg of ?-tocopherol). At the end of the study, the vitamins group showed a lower LHP and MDA concentration in peripheral blood when compared to the control group, from the third and fourth month of intervention (p ‹ 0.05), respectively. The intragroupal anlysis of oxidative stress markers showed a lower concentration of both oxidative stress markers since the third month o intervention in the vitamins group (p ‹ 0.05). No differences were fround in the control group.
Conclusion: The high-in vitamins C and E diet diminished peripheral oxidative stress markers in women with endometriosis after four months of intervention.


REFERENCES

  1. Ruiz-Velasco V. Endometriosis. México: Intersistemas Editores; 2004, p. 1-77

  2. Preciado R, Torres J, Zúñiga JA, Martínez JC, Manterota D, García A. Incidencia de la endometriosis en mujeres con infertilidad: características clínicas y laparoscópicas. Ginecol Obstet Mex 2005; 73: 471-6.

  3. Donnez J, Van Langendonckt A, Casanas- Roux F (citar 6 autores) cols. Current thinking on the pathogenesis of endometriosis. Gynecol Obstet Invest 2002; 54: 52-62.

  4. Santanam N, Murphy AA, Parthasarathy S. Macrophages, oxidation, and endometriosis. Ann NY Acad Sci 2002; 955: 183-98; discussion 19-200, 396-406. Review.

  5. González MC, Betancourt M, Ortiz R. Daño oxidativo y antioxidantes. Bioquímica 2000; 25: 3-9.

  6. Céspedes T, Sánchez D. Algunos aspectos sobre el estrés oxidativo, el estado antioxidante y la terapia de suplementación. Rev Cubana Cardiol 2000; 14: 55-60.

  7. Willcox JK, Ash SL, Catingnani GL. Antioxidants and prevention of chronic disease. Critical Reviews in Food Science and Nutrition 2004; 44: 275-85.

  8. Rodríguez JM, Menéndez JR, Trujillo Y. Radicales libres en la biomedicina y estrés oxidativo. Rev Cubana Med Milit 2001; 30: 36-44.

  9. Pfeffer F, Casanueva E. Vitamina C. En: Bourges H, Casanueva E, Rosado JL (eds.). Recomendaciones de ingestión de nutrimentos para la población mexicana. México: Editorial Médica Panamericana; 2005, p. 77-87.

  10. Cadenas E, Packer L. Handbook of antioxidants. 2a. Ed. Nueva York: Marcel Dekker, Inc.; 2001, p. 1-145.

  11. Hernández C, Bujalil L, De la Jara J, Mier J, Bouchán P. Endometriosis y consumo deficiente de moléculas antioxidantes relacionado con estrés oxidativo periférico y peritoneal. Ginecol Obstet Mex 2006; 74: 20-8.

  12. Casanueva E, Kaufer-Horwitz M, Pérez- Lizaur AB, Arroyo P (eds.). Nutriología Médica. 2a. Ed. México: Editorial Médica Panamericana; 2001, p. 443, 537, 541, 598.

  13. Asociación Médica Mundial. Declaración de Helsinki de la Asociación Médica Mundial, principios éticos para las investigaciones médicas en seres humanos. Tokio 2004.

  14. Pérez AB, Marván L. Sistema Mexicano de Alimentos Equivalentes. México: Fondo de Nutrición y Salud A.C.; 2001.

  15. Muñoz M, Chávez A y (citar 6 autores) col. Tablas de valor nutritivo de los alimentos. México: Editorial Pax México; 1996. p. 51-150.

  16. USDA National Nutrient Database for Standard Reference, Release 18 Vitamin E (alpha-tocopherol) (mg) Content of Selected Foods per Common Measure. 2005. Disponible en: http://www.nal.usda.gov/fnc/foodcomp/Data/SR18/nutrlist/r18w323.pdf

  17. Hernandez-Avila M, Romieu I, Parra S, Hernandez-Avila J, Madrigal H, Willett W. Validity and reproducibility of a food frequency questionnaire to assess dietary intake of women living in Mexico City. Salud Publica Mex 1998; 40: 133-40.

  18. Cox K. Food Processor for Windows Nutrition Analysis Software. Version 8.3.0, Oregon: ESHA Research, 2004.

  19. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by Thiobarbituric Acid Reaction. Anal Biochem 1979; 95: 351-8.

  20. Jiang ZY, Hunt JV, Wolf SP. Detection of lipid hydroperoxides using Fox method. Anal Biochem 1992; 202: 384-9.

  21. Lee RD, Nieman DC. Nutritional assessment. 3a. Ed. New York: McGraw-Hill Higher Education; 2003. p. 180-95.

  22. Rock J. The revised American Fertility Society classification of endometriosis: reproducibility of scoring. ZOLADEX Endometriosis Study Group. Fertil Steril 1995; 63: 1108-10.

  23. Villalpando S, Caraveo V, Valdés-Ramos R. Vitamina A y carotenos. En: Bourges H, Casanueva E, Rosado JL, (eds.). Recomendaciones de ingestión de nutrimentos para la población mexicana. México, D.F.: Editorial Médica Panamericana; 2005. p. 27-39.

  24. Kaufer-Horwitz M, Aguilar CA. Vitamina E. En: Bourges H, Casanueva E, Rosado JL (eds.). Recomendaciones de ingestión de nutrimentos para la población mexicana. México, D.F.: Editorial Médica Panamericana; 2005. p. 55-63.

  25. Jialal I, Fuller CJ. Effect of vitamin E, vitamin C and betacarotene on LDL oxidation and atheroesclerosis. Can J Cardiol 1995; 11; 97G-113G.

  26. Mayne ST. Antioxidant nutrients and chronic disease: use of biomarkers of exposure and oxidative stress status in epidemiological research. J Nutr 2003; 933S-40S.

  27. Huang HY, Appel JL, Croft KD, Miller III ER, Mori TA, Puddey IB. Effects of vitamin C and vitamin E on in vivo lipid peroxidation: results of a randomized controlled trial. Am J Clin Nutr 2002; 76: 549-55.

  28. Frei B, England L, Ames BN. Ascorbate is an outstanding antioxidant in human blood plasma. Proc Nat Acad Sci USA 1989; 86: 6377-81.

  29. Frei B. Ascorbic acid protects lipids in human plasma and low-density lipoprotein against oxidative damage. Am J Clin Nutr 1991; 54: 1113S-8S.

  30. Hillstrom RJ, Yacapin-Ammons AK, Lynch SM. Vitamin C inhibits lipid oxidation in human HDL. J Nutr 2003; 133: 3047-51.

  31. Esterbauer H, Dieber-Rotheneder M, Striegl G, Waeg G. Role of vitamin E in preventing the oxidation of low density lipoprotein. Am J Clin Nutr 1991; 53: 314S-21S.

  32. Chan Ac. Partners in defense, vitamin E and vitamin. Can J Physiol Pharmacol 1993; 71: 725-31.

  33. Sato K, Niki E, Shimasaki H. Free radicalmediated chain oxidation of low density lipoprotein and its synergistic inhibition by vitamin E and vitamin C. Arch Biochem Biophys, 1990; 279: 402-5.

  34. Dragsted LO, Pederson A, Remeter A (citar 6 autores) and cols. The 6-a-day study: effects of fruit and vegetables on markers of oxidative stress and antioxidative defense in healthy nonsmokers. Am J Clin Nutr 2004; 79: 1060-72.

  35. Brown K, Morrice P, Duthie G. Vitamin E supplementation suppresses indexes of lipid peroxidation and platelet counts in plasma lipoprotein concentrations remain unchanged. Am J Clin Nutr 1994; 60: 383-7.

  36. Huang HY, Appel LJ, Croft KD, Miller ER, Mori TI, Puddey IB. Effects of vitamin C and vitamin E on in vivo lipid peroxidation: results of a randomized controlled trial. Am J Clin Nutr 2002; 76: 549-55.

  37. Donnez J, Van Langendonckt A, Casanas-Roux F (citar 6 autores) and cols. Current thinking on the pathogenesis of endometriosis. Gynecol Obstet Invest 2002; 54: 52-62.

  38. Jackson LW, Schisterman EF, Dey-Rao R, Browne R, Armstrong D. Oxidative stress and endometriosis. Hum Reprod 2005; 20(7): 2014-20.

  39. Parazzini F, Chiaffarino F, Surace M (citar 6 autores) and cols. Selected food intake and risk of endometriosis. Hum Reprod 2004; 19: 1755-9.

  40. Agarwal A, Makker K, Sharma R. Clinical relevance of oxidative stress in male factor infertility: an update. Am J Reprod Immunol 2008; 59(1): 2-11.

  41. Agarwal A, Gupta S, Sikka S. The role of free radicals and antioxidants in reproduction. Curr Opin Obstet Gynecol. 2006; 18(3): 325-32.

  42. Agarwal A, Gupta S, Sharma R. Oxidative stress and its implications in female infertility - a clinician’s perspective. Reprod Biomed Online 2005; 11(5): 641-50.




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