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ISSN 0185-6014 (Print)
Órgano oficial de difusión de la Federación Mexicana de Patología Clínica, AC y de la Asociación Latinoamericana de Patología Clínica/Medicina de Laboratorio

2005, Number 1

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Rev Mex Patol Clin Med Lab 2005; 52 (1)

TrkB: possible target in the treatment of neuroblastoma

Díaz-Rosales JD, Loera OF, Romo JE, Ortiz-Morales L

Language: Spanish
References: 20
Page: 13-17
PDF size: 92.70 Kb.


ABSTRACT

Neuroblastomas tumors expressing high levels of TrkB and brain derived neurotrophic factor (BDNF) are associated with poor prognosis. Diverse studies indicated that BDNF/TrkB are capable to decrease the chemosensitivity of neuroblastoma to agents of chemotherapy. It is evident that BDNF/TrkB contribute to the chemoresistance of neuroblastomas and that inhibition of PI-3K path could improve action of agents of chemotherapy.


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