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ISSN 0185-3252 (Print)
Revista de la Asociación Médica del Centro Médico ABC

2008, Number 4

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An Med Asoc Med Hosp ABC 2008; 53 (4)

Sexual hormone binding globulin (SHBG) and preeclampsia

Briones VG, Quiroz RJ, Díaz LPM, Briones GJC, González RM, Ayala AR

Language: Spanish
References: 10
Page: 181-183
PDF size: 69.26 Kb.


ABSTRACT

Maternal and fetal health complications due to preeclampsia along with its unknown etiology have made searching of a diagnostic marker an imperative. Former measurements of sexual hormone binding globulin (SHBG) in serum of patients with preeclampsia was found to be decreased even before the second half of gestation, opening the possibility as a mean of prevention. Hence we measured serum SHBG concentrations through radioimmunoassay in women with preeclampsia and normal pregnancy (controls). Women with gestational hypertensive disease, unexpectedly exhibited significant (p‹0.01) higher levels of SHBG than normal pregnant females, contrary to previous observations and despite the hypoproteinemic condition prevailing in preeclampsia.


REFERENCES

  1. Ayala A. Endocrinología del embarazo. En: Medicina de la Reproducción Humana. México, DF: Azabache 2006. p. 424-440.

  2. Leaños MA, Marquez AJ, Cardenas MGP, Chinolla-Arellano ZL, Rivera LR, Bermejo HS, Romero AJF, Alvarez JG, Ramos LJC, Ulloa AA. Urinary prolactin as a reliable marker for preeclampsia, its severity, and the ocurrence of adverse pregnancy outcomes. J Clin Endocrinol Metab 2008; 93: 2492-2499.

  3. National High Blood Pressure Education Program Working Group on high blood pressure during pregnancy. Am J Obstet Gynecol 1990; 163: 1689-1712.

  4. Wolf M, Sandler L, Muñoz K, Hsu K, Ecker JL, Thadhani R. First trimester insulin resistance and subsequent preeclampsia: a prospective study. J Clin Endocrinol Metab 2002; 87: 1563-1568.

  5. Yen SSC, Jaffe R. Androgens and reproduction. In: Reproductive Endocrinology. New York: Saunders. 2006. p. 780-998.

  6. ESHE/ASRM. Revised 2003 consensus on diagnostic criteria and long term health risks related to polycystic ovary syndrome. Fertil Steril 2004; 81: 19-25.

  7. Farag K, Hassan I, Ledger WL. Prediction of preeclampsia: Can it be achieved? Obstet Gynec Surv 2004; 59: 464-482.

  8. Seely EW, Solomon G. Insulin resistance and its potential role in pregnancy induced hypertension. J Clin Edocrinol Metab 2003 ; 88: 2392-2398.

  9. Wilson ML, Murphy T, Parn VL, Inles SA. Molecular epidemiology of preeclampsia. Obstet Gynecol Surv 2002; 58: 39-66.

  10. López LM, Díaz de León M, Rodríguez AJ, Ayala AR. Preeclampsia-eclampsia: Un problema médico diferido. Gac Med Mex 1999 ; 135: 397-405.




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