medigraphic.com
ISSN 0185-6014 (Print)
Órgano oficial de difusión de la Federación Mexicana de Patología Clínica, AC y de la Asociación Latinoamericana de Patología Clínica/Medicina de Laboratorio

2009, Number 1

<< Back Next >>

Rev Mex Patol Clin Med Lab 2009; 56 (1)

Lipid´s alterations of newborn caused by smoking and hypertension on their mothers

Ruiz MAA, González GOL, Delmés LY, Burgos BD, Sarduy SJ

Language: Spanish
References: 17
Page: 4-9
PDF size: 68.91 Kb.


ABSTRACT

Objectives: To analyze the effects over the cholesterol and triglycerides (or triacylglycerides) levels in neonates by smoking and hypertension on their mothers. Methods: Transversal descriptive study that took 181 neonates and 140 mothers from «Mártires del 9 de Abril» hospital in Sagua la Grande in Villa Clara´s province, Cuba. The neonates were stratified according to their mothers, being normals, hypertensives or smokers. Total cholesterol and triglycerides were determined in the blood samples of the umbilical cord of the newborns and in the vein blood serum obtained from the mothers after partum. The lipids mentioned were compared to groups (neonates and their mothers) and intergroups (neonates of healthies, hypertensives and smokers mothers) using the test t of the Student to compare the means. Results: the total cholesterol levels and triglycerides in newborn were very low to their mothers. Those newborns whose mothers were hypertensives or smokers had descriptively high levels of this lipid than their similar from healthy mothers. Just the triglycerides showed statistics differences (p ‹ 0.001) to those whose mothers were hypertensive. Conclusions: The arterial hypertension and smoking during the gestation should be controlled or avoided because they can affect negatively over the lipid profile of newborn.


REFERENCES

  1. Herrera E. Lipid metabolism in pregnancy and its consequences in the fetos and newborn. Endocrine 2002; 19 (1): 43-55.

  2. Graham I, Atar D, Borch-Johnsen K, Blysen G, Burell G, Cifkova R et al. Guías de práctica clínica sobre prevención de la enfermedad cardiovascular: Versión resumida. Rev Exp Cardiol 2008; 61 (1): e1-e49.

  3. Rafsted S. Lípidos del suero del recién nacido. Acta Pediátrica (UPPSALA) 1954; 43: 229.

  4. Juárez IE, Rivera G, Mejía JM, Mercado JA, Díaz S. Lipid profile in healthy newborn infants and its correlation with maternal lipid levels. Sal Pub Mex 1999; 41 (5): 405-409.

  5. Mahley RW, Aíslan P, Pekcan G, Pepin GM, Agacdiken A, Karaagoglu N et al. Plasma lipids in Turkish children: Impact of puberty, socioeconomic status, and nutrition on plasma cholesterol and HDL. J Lipid Res 2001; 42 (12): 1996-2006.

  6. Qureshi IA, Xi XR, Pasha N, Zheng HA, Huang YB, Wu XD. Hyperlipidemia of normal pregnancy in Karachi-Pakistan. Kaohsiung J Med Sci 1999; 15 (9): 529-535.

  7. Silliman K, Kretchmer N. Maternal obesity and body composition of the neonate. Biol Neonate 1995; 68: 384-393.

  8. Harnosh M. Lipid metabolism in the fetus. In: Polin RA, Fox WW. Fetal and neonatal physiology. Lipid metabolism in the fetus. WB Saunders 1992 p. 291-299.

  9. Bastida S, Sánchez-Muñiz FJ, Cuesta C, Perea S, Aragonés A. Male and female cord blood lipoprotein profile differences throught the term period. J Perinat Med 1997; 25: 184-191.

  10. Miller M, Bchurick SP, Cloeey A. Normal variations of plasma concentrations of lipids, lipoproteins and apolipoproteins. Clin Chem 1992; 38: 569-574.

  11. Valdéz MJ, Cardellá RL, Gómez AA. Comparación entre los valores de variables lipídicas de los recién nacidos de madres sanas y los recién nacidos de madres con algún factor de riesgo aterogénico. Rev Cub Invest Biomed. [online]. 2007; 26 (2): 0-0. Disponible en: http://scielo.sld.cu/scielo.php?script= sci_arttext&pid=s0854-03002007000200003&ing= es&nrm=iso ISSN 0864-0300.

  12. Behrman RE, Kliegman RM, Harbin AM. Nelson Tratado de Pediatría Vol 1. 15a ed. Ciudad de La Habana: Ed Ciencias Médicas; 1998. p. 475.

  13. Pulzer F, Haase V, Kratzsch J, Richter V, Rassoul F, Kiess W et al. Lipoprotein (a) levels in formerly small-for-gestational-age children. Horm Res 1999; 52 (5): 241-246.

  14. Molina M, Casanueva Y, Cid K, Ferrada MC, Pérez R, Dios G et al. Lipid profile in newborns with intrauterine growth retardation. Rev Med Chil 2000; 128 (7): 741-748.

  15. Iscan A, Yigitoglu MR, Ece A, Ari Z, Akyildiz M. The effect of cigarette smoking during pregnancy on cord blood lipid, lipoprotein and apolipoprotein levels. Jpn Heart J 1997; 38 (4): 497-502.

  16. 16.Executive summary of the third report of the National Cholesterol Education Program (NCEP). Expert panel on detection, evaluation and treatment of high blood cholesterol in adults (Adults Treatment Panel III). JAMA 2001; 285: 2486-2497.

  17. III Directrizes brasileiras sobre dislipidemias e directriz de prevensao da aterosclerose do departamento de aterosclerose da Sociedade Brasileira de Cardiologia. Arq Bras Cardiol 2001; 77 (3).




2020     |     www.medigraphic.com