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2008, Number 4

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Rev Med Hosp Gen Mex 2008; 71 (4)

Human herpesvirus-6 (HHV-6) is a possible cardiac pathogen: An immunopathological and ultrastructural study

Krueger GRF, Rojo J, Maximilian BL, Lassner D, Kuehl U

Language: English
References: 17
Page: 187-191
PDF size: 447.03 Kb.


ABSTRACT

Human Herpesvirus-6 (HHV-6), a lymphotropic and neurotropic virus, potentially infects cells with the complement receptor CD46 and may cause significant disease. Although cardiomyocytes do not seem to express significant amounts of the CD46 receptor, cardiac symptoms were previously described in patients with active HHV-6 infection. We have thus studied biopsy and autopsy tissues from serologically HHV-6 positive patients with various cardiac diseases. Diseases include dilated cardiomyopathy in HIV1+/AIDS, other cardiomyopathies or myocarditis, and status post cardiac transplantation. Techniques used include immunohistochemistry for HHV-6 antigens, in situ hybridization for HHV-6 DNA, as well as electron microscopy for viral particles. Viral antigens, DNA and viral particles were identified preferentially in vascular endothelial cells, but only occasionally in single degenerating cardiomyocytes. An endothelial dysfunction and microvascular disease is discussed as possible pathogenesis of HHV-6 associated cardiovascular diseases.


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