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2004, Number 2

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Rev Med Inst Mex Seguro Soc 2004; 42 (2)

Acute Lymphoblastic Leukemia.Neuropsychologic Alterations Associated with Central Nervous System Prophylactic Treatment

Lavielle P, Rozen E, Avilés H, Hernández A, Grijalva I

Language: Spanish
References: 31
Page: 167
PDF size: 59.82 Kb.


ABSTRACT

Objective: our objective was to determine the association between cognitive alterations and prophylactic treatment to the central nervous system (CNS). Material and methods: we evaluated, by means of a standardized neuropsychologic test, adults with diagnosis of acute leukemia who received prophylactic treatment to CNS, and patients with Hodgkin lymphoma as control group. Results: global evaluation of the neuropsychologic test in each group showed that 16.7 % of patients with acute leukemia and 13.3 % of patients with Hodgkin lymphoma obtained scores that exhibit-ed slight cognitive damage (OR = 1.3, CI 95 % = 0.312-5.4). In partial evaluation of each cognitive ability, patients with ALL presented disturbances with greater frequency than the group with Hodgkin lymphoma (attention OR = 3, CI 95 % = 1.04-8.6; memory OR =1.8, CI 95 % = 0.61-5.2; and lan-guage OR = 2, CI 95 % = 0.7-5.67). Conclusions: patients who received prophylactic treatment to CNS presented some type of dis-turbance of the cognitive functions, with greater frequency than did patients who did not receive this treatment. Although it was not demonstrated that prophylaxis of CNS was associated with a specific neurologic syndrome, it was found associated with the disturbance of some of the functions, specifically with attention and concentration.


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