medigraphic.com
Patología Revista Latinoamericana

2008, Number 3

<< Back Next >>

Patol Rev Latinoam 2008; 46 (3)

Invasive micropapillary carcinoma, an aggressive variant of breast carcinoma. Review of the entity in regard to 12 cases

Padilla RAL

Language: Spanish
References: 28
Page: 215-221
PDF size: 388.41 Kb.


ABSTRACT

Background: Invasive micropapillary carcinoma of the breast is a rare subtype of breast cancer with particular histologic features, related to more aggressive behavior and poorer prognosis. Objective: To report the clinicopathologic and immunohistochemical features of 12 cases of infiltrating ductal breast carcinoma, with invasive micropapillary component. Material and method: Twelve cases of breast cancer with invasive micropapillary carcinoma components from 2001 to 2006. Biopsies, mastectomized glands, and material from surgical pathology department of Centro Medico ABC, all studied through paraffin technique and hematoxiline-eosine stein. Results: The mean age of patients was 50 years (range 26 to 88 years); most of cases were histological grade 2 or 3; every case showed lymphatic invasion; dissections of axillary lymph nodes in seven of eight cases showed metastasis; the number of positive lymph nodes ranged from 1 to 15; nine cases were positive for estrogen and progesterone receptors; seven cases were positive for CerbB-2, among these, 5 were highly positive (3+); p53 was positive in variable percentages; cellular proliferation index and vascular density were also variable; six of eight cases had abnormal nuclear ploidy. Conclusion: A micropapillary component in a breast carcinoma is associated with a high risk of lymphovascular invasion and nodal metastasis, thus finding it is crucial for determining prognosis and an accurate patient management.


REFERENCES

  1. Page DL. Special types of invasive breast cancer, with clinical implications. Am J Surg Pathol 2003;27:832-5.

  2. Siriaunkgul S, Tavassoli FA. Invasive micropapillary carcinoma of the breast. Mod Pathol 1993;6:660-2.

  3. Paterakos M, Watkin WG, Edgerton SM, Moore D, Thor A.Invasive micropapillary carcinoma of the breast: a prognostic study. Hum Pathol 1999;30:1459-63.

  4. Nassar H, Wallis T, Andea A, Dey J, et al. Clinicopathologic analysis of invasive micropapillary differentiation in breast carcinoma. Mod Pathol 2001;14:836-41.

  5. Zekioglu O, Erhan Y, Ciris M, Bayramoglu H, Ozdemir N. Invasive micropapillary carcinoma of the breast: high incidence of lymph node metastasis with extranodal extension and its immunohistochemical profile compared with invasive ductal carcinoma. Histopathology 2004;44:18-23.

  6. Fu L, Ikuo M, Fu XY, Liu TH, Shinichi T. Relationship between biologic behavior and morphologic features of invasive micropapillary carcinoma of the breast. Zhonghua Bing Li Xue Za Zhi 2004;33:21-25.

  7. Kuroda H, Sakamoto G, Ohnisi K, Itoyama S. Clinical and pathologic features of invasive micropapillary carcinoma. Breast Cancer 2004;11:169-174.

  8. Pettinato G, Manivel CJ, Panico L, Sparano L, Petrella G. Invasive micropapillary carcinoma of the breast: clinicopathologic study of 62 cases of a poorly recognized variant with highly aggressive behavior. Am J Clin Pathol 2004;121:857-66.

  9. Gunhan-Bilgen I, Zekioglu O, Ustun EE, Memis A, Erhan Y. Invasive micropapillary carcinoma of the breast: clinical, mammographic, and sonographic findings with histopathologic correlation. AJR Am J Roentgenol 2002;179:927-31.

  10. Kim MJ, Gong G, Joo HJ, Ahn SH, Ro JY. Immunohistochemical and clinicopathologic characteristics of invasive ductal carcinoma of breast with micropapillary carcinoma component. Arch Pathol Lab Med 2005;129:1277-82.

  11. Luna-More S, Gonzalez B, Acedo C, Rodrigo I, Luna C.Invasive micropapillary carcinoma of the breast: a new special type of invasive mammary carcinoma. Pathol Res Pract 1994;190:668-74.

  12. Nassar H. Carcinomas with micropapillary morphology:clinical significance and current concepts. Adv Anat Pathol 2004;11:297-303.

  13. Tresserra F, Grases PJ, Fabregas R, Fernandez-Cid A, Dexeus S. Invasive micropapillary carcinoma. Distinct features of a poorly recognized variant of breast carcinoma. Eur J Gynaecol Oncol 1999;20:205-8.

  14. Walsh MM, Bleiweiss IJ. Invasive micropapillary carcinoma of the breast: eighty cases of an underrecognized entity. Hum Pathol 2001;32:583-9.

  15. De La Cruz C, Moriya T, Endoh M, Watanabe M, et al. Invasive micropapillary carcinoma of the breast: clinicopathological and immunohistochemical study. Pathol Int 2004;54:90-96.

  16. Gong Y, Sun X, Huo L, Wiley EL, Rao MS. Expression of cell adhesion molecules, CD44s and E-cadherin, and microvessel density in invasive micropapillary carcinoma of the breast. Histopathology 2005;46:24-30.

  17. Guo XJ, Chen L, Lang RG, Fan Y, Fu L. Relationship between lymph node metastasis and pathologic features of invasive micropapillary carcinoma of breast. Zhonghua Bing Li Xue Za Zhi 2006;35:8-12.

  18. Varga Z, Zhao J, Ohlschlegel C, Odermatt B, Heitz PU. Preferential HER-2/neu overexpression and/or amplification in aggressive histological subtypes of invasive breast cancer. Histopathology 2004;44:332-338.

  19. Kuroda H, Sakamoto G, Ohnisi K, Itoyama S. Overexpression of Her2/neu, estrogen and progesterone receptors in invasive micropapillary carcinoma of the breast. Breast Cancer 2004;11:301-6.

  20. Luna-More S, Casquero S, Perez-Mellado A, Rius F, et al.Importance of estrogen receptors for the behavior of invasive micropapillary carcinoma of the breast. Review of 68 cases with follow-up of 54. Pathol Res Pract 2000;186:35-39.

  21. Luna-More S, de los Santos F, Breton JJ, Canadas MA. Estrogen and progesterone receptors, c-erbB-2, p53, and Bcl-2 in thirty-three invasive micropapillary breast carcinomas. Pathol Res Pract 1996;192:27-32.

  22. Fan Y, Lang RG, Wang Y, Sun BC, Fu L. Relationship between expression of cell adhesion molecules and metastatic potential in invasive micropapillary carcinoma of the breast. Zhonghua Bing Li Xue Za Zhi 2004;33:308-11.

  23. Nagi C, Guttman M, Jaffer S, Qiao R, et al. N-Cadherin expression in breast cancer: correlation with an aggressive histologic variant-invasive micropapillary carcinoma. Breast Cancer Res Treat 2005;94:225-35.

  24. Ibarra JA. Papillary lesions of the breast. Breast J 2006;12:237-251.

  25. Nassar H, Pansare V, Zhang H, Che M, et al. Pathogenesis of invasive micropapillary carcinoma: role of MUC1 glycoprotein. Mod Pathol 2004;17:1045-50.

  26. Li YS, Kaneko M, Sakamoto DG, Takeshima Y, Inai K. The reversed apical pattern of MUC1 expression is characteristic of invasive micropapillary carcinoma of the breast. Breast Cancer 2006;13:58-63.

  27. Khayyata S, Basturk O, Adsay NV. Invasive micropapillary carcinomas of the ampullo-pancreatobiliary region and their association with tumor-infiltrating neutrophils. Mod Pathol 2005;18:1504-11.

  28. Thor AD, Eng C, Devries S, Paterakos M, et al. Invasive micropapillary carcinoma of the breast is associated with chromosome abnormalities detected by comparative genomic hybridization. Hum Pathol 2002;33:628-31.




2020     |     www.medigraphic.com