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Patología Revista Latinoamericana

2008, Number 3

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Patol Rev Latinoam 2008; 46 (3)

Expression of MMP-1 and MMP-11 in squamous cell carcinoma of the nasal cavity and paranasal sinuses

Suárez RML, Asbun J, Ruiz A, Ruiz GLM, Meneses GA

Language: Spanish
References: 17
Page: 204-214
PDF size: 254.68 Kb.


ABSTRACT

Background: Poor prognosis in patients with squamous cell carcinoma of the nasal cavity and paranasal sinuses is associated mainly with invasion, recurrence, and loco-regional metastases. Objective: To evaluate the expression of MMP-1 and -11 in NCPS squamous cell carcinoma. Patients and method: Seventeen patients with complete clinical record, no treatment before the initial diagnostic biopsy, and adequate material for the immunohistochemical study of MMP-1 and MMP-11. x2 and Fisher’s exact test were used to assess MMP-1 and MMP-11 expression of neoplastic and peritumoral fibroblasts and its relation to clinicopathological parameters. Results: We found 10 females and 7 males with 58 years old mean age (37 to 85); two were classified as clinical stage II, six as III, and nine as IV. For MMP-1, 13 cases (76%) were positive in neoplastic cells and 13 in peritumoral fibroblasts. For MMP-11, 12 (71%) were positive in neoplastic cells and 10 (59%) in peritumoral fibroblasts. Conclusions: MMP-1 and MMP-11 are expressed in squamous cell carcinoma of the nasal cavity and paranasal sinuses by both neoplastic cells and peritumoral fibroblasts, suggesting that they might be exerting adjuvant actions in the mechanisms of tumor progression and that their low expression could be related to a favorable prognosis.


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