2008, Number 2
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Patol Rev Latinoam 2008; 46 (2)
Gliosarcoma, report of two autopsy cases and one biopsy at Hospital General de Mexico
Velázquez GG, Lara TH, Hernández GM, Soriano RJ, Chávez ML, Olvera RJE
Language: Spanish
References: 13
Page: 96-100
PDF size: 963.05 Kb.
ABSTRACT
The gliosarcoma had been considered a neoplasia with an astrocytic and mesenchymal fusocellular components, the latter originated from the wall of newly formed vessels. Based on molecular biology studies, it is now known that both cells belong to the same clone, even though they have different phenotype. The average age at presentation is 53 years and the most common location is the temporal lobe, followed by the parietal and frontal. The evolution is short with intracranial hypertension and focal neurologic signs. They make up 2% of glioblastomas. Three cases have been studied in the Hospital General de Mexico, one woman and two men aged 53, 65 and 17 years. One was a surgical specimen and two were autopsies. Grossly they were well circumscribed and hard. In one, a subtotal resection was made and a large hematoma with little residual tumor was found. The astrocytic component was in some areas intermingled and in others surrounded by fusocellular elements separated by abundant reticular and collagen fibers. The gliosarcoma is an infrequent neoplasm, with clinical evolution similar to the ordinary glioblastoma. The former tumor can be usually differentiated from the latter by the good circumscription ad by its consistency, much harder than the surrounding tissue.
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