Carranza MJ, Alvizouri MM, Herrera AJE, Chávez CF

Language: Spanish
References: 22
Page: 267-272
PDF size: 261.00 Kb.

ABSTRACT

Background: Avocado as a source of monounsaturated acid fat has beneficial effects on lipid profile and endothelial function in diabetic and metabolic syndrome patients, and may reduce insulin sensitivity and risk of atherothrombotic events.
Objective: To determine avocado’s effect on lipids, glucose metabolism, and rheologic parameters in patients with type 2 diabetes.
Patients and method: 21 patients with type 2 diabetes were assigned to two groups with 1,700 kcal/day diet during four weeks, in a randomized, open, blind for laboratory evaluators, and cross-over study. Diet in group 1 was avocado-free, with 50% of carbohydrates, 20% of proteins and 30% of fat in accordance with American Diabetes Association statements; and in group 2, with avocado and 75% of total fat was provided by Hass variety. Fasting plasma glucose, postprandial glucose, glycosilated hemoglobin, insulin sensitivity (by HOMA method), total cholesterol, triglycerides, HDL cholesterol, serum lipoperoxidation, platelet aggregation, blood viscosity, and osmotic fragility of erythrocytes were measured, and LDL cholesterol estimated at basal and after each diet.
Results: Both diets resulted in reductions of fasting plasma glucose, glycosilated hemoglobin, insulin sensitivity (significantly lower in group 2), total cholesterol, triglycerides, LDL cholesterol, and blood viscosity. None of them modified HDL cholesterol values. Group 2 diet increased serum lipoperoxidation and reduced platelet aggregation 90 seconds after the stimulus, and increased osmotic fragility of erythrocytes.
Conclusions: Avocado can be used in dietary treatment of type 2 diabetes with some advantages over traditional diets used for that purpose.

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