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Anales de Otorrinolaringología Mexicana

2008, Number 1

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Otorrinolaringología 2008; 53 (1)

Kikuchi-Fujimoto disease: a report of a case and bibliographic review

Morales CM, Núñez ZG, Pérez BN, Ladrón GMM

Language: Spanish
References: 41
Page: 35-40
PDF size: 205.95 Kb.


ABSTRACT

Kikuchi-Fujimoto disease (KFD) or histiocytic necrotizing lymphadenitis is a benign and self-limited disorder, characterized by regional cervical lymphadenopathy with tenderness, usually accompanied with mild fever and night sweats. This is an extremely rare disease known to have a worldwide distribution with higher prevalence among Asian individuals. It is a very rare entity in Mexican population. While its etiology remains unclear, lately it has been associated with Epstein-Barr virus and human herpesvirus-6. Histologically, KFD findings include paracortical areas of coagulative necrosis with abundant karyorrhectic debris. It is clinically significant because of the possible misdiagnosis of other diseases such as tuberculosis, lymphoma, lymphadenitis associated with systemic lupus erythematosus, and even adenocarcinoma. Treatment is symptomatic. Spontaneous recovery occurs in 1 to 4 months. Patients with Kikuchi-Fujimoto disease should be followed-up for several years to survey the possibility of developing systemic lupus erythematosus. KFD is an uncommon, self-limited, and perhaps underdiagnosed process with an excellent prognosis. Accurate clinical-pathologic recognition is crucial, in order to prevent misdiagnosis and inappropriate treatment, particularly because KFD can be mistaken for malignant lymphoma. This paper serves to update otolaryngologists about the most current theories on a lesser known etiology of a self-limiting neck mass, especially in young individuals with posterior cervical lymphadenopathy. We present a case study of a 28 year-old Chinese male immigrant who presented with a unilateral cervical posterior neck mass and provide a literature review about KFD.


REFERENCES

  1. Kikuchi M. Lymphadenitis showing focal reticulum cell hyperplasia with nuclear debris and phagocytes: A clinical-pathological study. Nippon Ketsueki Gakkai Zasshi 1972;35:379-80.

  2. Fujimoto Y, Kozima Y, Yamaguchi K. Cervical subacute necrotizing lymphadenitis. A new clinical-pathologic entity. Naika 1972;20:920-7.

  3. Pileri S, Kikuchi M, Helbron D, Lennert K. Histiocytic necrotizing lymphadenitis without granulocytic infiltration. Virchows Arch A Pathol Anat Histol 1982;395:257-71.

  4. Turner RR, Martin J, Dorfman RF. Necrotizing lymphadenitis: a study of 30 cases. Am J Surg Pathol 1983;7:115-23.

  5. Rivano MT, Falini B, Stein H, Canino S et al. Histiocytic necrotizing lymphadenitis without granulocytic infiltration (Kikuchi’s lymphadenitis). Morphological and immunohistochemical study of eight cases. Histopathology 1987;11:1013-27.

  6. Dorfman RF, Berry GJ. Kikuchi’s histiocytic necrotizing lymphadenitis: an analysis of 108 cases with emphasis on differential diagnosis. Semin Diagn Pathol 1988;5:329-45.

  7. Chamulak GA, Brynes RK, Nathwani BN. Kikuchi-Fujimoto disease mimicking malignant lymphoma. Am J Surg Pathol 1990;14:514-23.

  8. Tsang WY, Chan JK, Ng CS. Kikuchi’s lymphadenitis. A morphologic analysis of 75 cases with special reference to unusual features. Am J Surg Pathol 1994;18:219-31.

  9. Kuo TT. Kikuchi’s disease (histiocytic necrotizing lymphadenitis). A clinical-pathological study of 79 cases with an analysis of histologic subtypes, immunohistology, and DNA ploidy. Am J Surg Pathol 1995;19:798-809.

  10. Tumiati B, Bellelli A, Portioli I, Prandi S. Kikuchi’s disease in systemic lupus erythematosus: an independent or dependent event? Clin Rheumatol 1991;10:90-93.

  11. Litwin MD, Kirkham B, Henderson DR, Milazzo SC. Histiocytic necrotising lymphadenitis in systemic lupus erythematosus. Ann Rheum Dis 1992;51:805-7.

  12. el-Ramahi KM, Karrar A, Ali MA. Kikuchi disease and its association with systemic lupus erythematosus. Lupus 1994;3:409-11.

  13. Eisner MD, Amory J, Mullaney B, Tierney L, Browner WS. Necrotizing lymphadenitis associated with systemic lupus erythematosus. Semin Arthritis Rheum 1996;26:477-82.

  14. Chen YH, Lan JL. Kikuchi disease in systemic lupus erythematosus: clinical features and literature review. J Microbiol Immunol Infect 1998;31:187-92.

  15. Kwon SY, Kim TK, Lee KY, Seol HY. CT findings in Kikuchi disease: Analysis of 96 cases. AJNR Am J Neuroradiol 2004;25:1099-102.

  16. Kikuchi M, Yoshizumi T, Nakamura H. Necrotizing lymphadenitis: possible acute toxoplasmic infection. Virchows Arch A Pathol Anat Histol 1977;376:247-53.

  17. Bennie MJ, Bowles KM, Rankin SC. Necrotizing cervical lymphadenopathy caused by Kikuchi-Fujimoto disease. Br J Radiol 2003;76:656-8.

  18. Bataille V, Harland CC, Behrens J, Cook MG, Holden CA. Kikuchi disease (histiocytic necrotizing lymphadenitis) in association with HTLV1. Br J Dermatol 1997;136:610-2.

  19. Huh J, Kang GH. Kaposi’s sarcoma-associated herpesvirus in Kikuchi’s disease. Hum Pathol 1998;29:1091-6.

  20. Meyer O, Kahn MF, Grossin M, Ribard P et al. Parvovirus B19 infection can induce histiocytic necrotizing lymphadenitis (Kikuchi’s disease) associated with systemic lupus erythematosus. Lupus 1991;1:37-41.

  21. Yufu Y, Matsumoto M, Miyamura T, Nishimura J, Nawata H, Ohshima K. Parvovirus B19-associated haemophagocytic syndrome with lymphadenopathy resembling histiocytic necrotizing lymphadenitis (Kikuchi’s disease). Br J Haematol 1997;96:868-71.

  22. Yen A, Fearneyhough P, Raimer SS, Hudnall SD. EBV-associated Kikuchi’s histiocytic necrotizing lymphadenitis with cutaneous manifestations. J Am Acad Dermatol 1997;36:342-6.

  23. Shirakusa T, Eimoto T, Kikuchi M. Histiocytic necrotizing lymphadenitis. Postgrad Med J 1988;64:107-9.

  24. Sierra ML, Vegas E, Blanco-Gonzalez JE, Gonzalez A, Martinez P, Calero MA. Kikuchi’s disease with multisystemic involvement and adverse reaction to drugs. Pediatrics 1999;104:e24.

  25. Spies J, Foucar K, Thompson CT, LeBoit PE. The histopathology of cutaneous lesions of Kikuchi’s disease (necrotizing lymphadenitis): a report of five cases. Am J Surg Pathol 1999;23:1040-7.

  26. Kuo TT. Cutaneous manifestation of Kikuchi’s histiocytic necrotizing lymphadenitis. Am J Surg Pathol 1990;14:872-6.

  27. Sumiyoshi Y, Kikuchi M, Takeshita M, Ohshima K. Immunohistological study of skin involvement in Kikuchi’s disease. Virchows Arch B Cell Pathol Incl Mol Pathol 1992;62:263-9.

  28. Sumiyoshi Y, Kikuchi M, Ohshima K, Masuda Y, Takeshita M, Okamura T. A case of histiocytic necrotizing lymphadenitis with bone marrow and skin involvement. Virchows Arch A Pathol Anat Histopathol 1992;420:275-9.

  29. Chan JK, Wong KC, Ng CS. A fatal case of multicentric Kikuchi’s histiocytic necrotizing lymphadenitis. Cancer 1989;63:1856-62.

  30. Tsai MK, Huang HF, Hu RH. Fatal Kikuchi-Fujimoto disease in transplant recipients: a case report. Transplant Proc 1998;30:3137-8.

  31. O’Grady J, Variend S. Child fatality associated with pathological features of histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease). Pediatr Pathol Lab Med 1998;18:79-88.

  32. Menasce LP, Banerjee SS, Edmondson D, Harris M. Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease): continuing diagnostic difficulties. Histopathology 1998;33:248-54.

  33. Ohshima K, Shimazaki K, Kume T, Suzumiya J, Kikuchi M. Perforin and Fas pathways of cytotoxic T-cells in histiocytic necrotizing lymphadenitis. Histopathology 1998;33:471-8.

  34. Felgar RE, Furth EE, Wasik MA, Salhany KE. Histiocytic necrotizing lymphadenitis (Kikuchi’s disease): in situ end-labeling, immunohistochemical, and serologic evidence supporting cytotoxic lymphocyte-mediated apoptotic cell death. Mod Pathol 1997;10:231-41.

  35. Liu Q, Ohshima K, Shinohara T, Kikuchi M. Apoptosis in histiocytic necrotizing lymphadenitis. Pathol Int 1995;45:729-734.

  36. Takakuwa T, Ohnuma S, Koizumi H. Involvement of cell-mediated killing in apoptosis in histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease). Histopathology 1996;28:41-48.

  37. Medeiros LJ, Kaynor B, Harris NL. Lupus lymphadenitis: report of a case with immunohistologic studies on frozen sections. Hum Pathol 1989;20:295-9.

  38. Onciu M, Medeiros LJ. Kikuchi-Fujimoto lymphadenitis. Adv Anat Pathol 2003;10:204-11.

  39. Jang YJ, Park KH, Seok HJ. Management of Kikuchi’s disease using glucocorticoid. J Laryngol Otol 2000;114:709-11.

  40. Gutierrez-Castro M, De León-Bojorge B, Cuesta-Mejías T, Baquera-Heredia J. Enfermedad de Kikuchi-Fujimoto (linfadenitis histiocítica necrosante). Estudio clínico-patológico e inmunohistoquímico de 14 casos y su diagnóstico diferencial con otras linfadenitis necrosantes reactivas y neoplásicas. Rev Invest Clin 2006;58:441-9.

  41. Bosch X, Guilabert A, Miquel R, Campo E. Enigmatic Kikuchi-Fujimoto disease: a comprehensive review. Am J Clin Pathol 2004; 122:141-52.




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