2008, Number 2
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Acta Pediatr Mex 2008; 29 (2)
Human papillomavirus infection in children and its association with sexual abuse
García-Piña CA, Loredo-Abdalá A, Sam-Soto S
Language: Spanish
References: 65
Page: 102-108
PDF size: 217.24 Kb.
ABSTRACT
Infection by human papillomavirus (HPV) is the most frequent sexually transmitted condition in the world. According to the World Health Organization (WHO) it is a public health problem. Genitoanal condilomatosis in a child is frequently associated with sexual abuse. Nevertheless, there are other forms of transmission which must be ruled out, i.e.:
Perinatal transmission: In uterus or at the time of the childbirth.
Horizontal transmission: A patient with cutaneous warts who touches his(her) genitals can become infected. If a child is touched in his(her) genital and/or anal area by an infected adult with hand lesions he(she) may become infected.
Sexual transmission: The Center of Detection and Prevention of Diseases of Atlanta and the American Academy of Pediatrics report that children may acquire secondary HPV as a result of sexual abuse. However the risk is low; if present it must be considered only as a suspicion. Therefore every patient should be evaluated by a multidisciplinary group in order to ascertain the different possible routes of transmission. An errouneous diagnosis can originate an inadequate handling of the case from the legal point of view and viceversa, of turning an innocent victim into an aggressor, or viceversa or else giving rise to emotional, social, legal and economic implications.
REFERENCES
Dunne EF, Markowitz LE. Genital human papillomavirus infection. Clin Infect Dis 2006;43:624-9.
Boralevi F. Condylomas in children. Ann Dermatol Venereol 2004;131:913-9.
National Cancer Institute, Division of Cancer Epidemiology.Viral Epidemiology Branch Research. Disponible en: http:// dceg.cancer.gov/viral-research.html
Vanhooteghem O. Anogenital condylomata in the children.Practice guidelines for a medical expertise. Rev Med Liege 2007;62:151-4.
Sinal SH. Human papillomavirus infections of the genital and respiratory tracts in young children. Semin Pediatr Infect Dis 2005;16:306-16.
Fischer G. Anogenital warts in children. Pediatr Dermatol 2006;23:291-3.
Hornor G. Ano-genital warts in children: Sexual abuse or not? J Pediatr Health Care 2004;18:165-70.
Scheurer ME, Tortolero-Luna G, Adler-Storthz K. Human papillomavirus Infection: biology, epidemiology, and prevention. Int J Gynecol Cancer 2005;15:727-46.
Muñoz, N. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 2003;348:6.
Edgren G, Sparen P. Risk of anogenital cancer after diagnosis of cervical intraepithelial neoplasia: a prospective populationbased study. Lancet Oncol 2007;8:311-16.
Body AS. Condylomata acuminata in the pediatric population.Am J Dis Child 1990;144:817-24.
Sinclair A, Woods CR, Kirse DJ, Sinal SH. Anogenital and respiratory tract human papillomavirus infections among children: age, gender and potential transmission through sexual abuse. Pediatrics 2005;116:815-25.
Kui LL. Condyloma acuminatum and human papillomavirus infection in the oral mucosa of children. Pediatr Dent 2003;25:149-53.
Silverberg MJ, Thorsen P. Condyloma in pregnancy is strongly predictive of juvenile-on-set recurrent respiratory papillomatosis. Obstet Gynecol 2003;101:645-52.
Marcoux D, Nadeau K, McCuaing C. Pediatric anogenital warts:A 7-year review of children referred to a tertiary- care hospital in Montreal, Canada. Pediatrics 2006;23:199-207.
Moscicki AB. Genital HPV infections in children and adolescents. Obstet Gynecol Clin North Am 1996;23:675-97.
World Health Organization. Human papillomavirus infection and cervicouterine cancer disponible en: http://www.who. int/vaccine_research/diseases/hpv/en/.
World Health Organization. Sexually transmitted disease.Three hundred and thirty three million new curable cases in 1995. Ginebra, 1995. 5. Zur-Hausen H. Papillomaviruses in human cancers. Proc Assoc Am Physicians 1999;111:581-7.
Lazcano E, Alonso P, Hernandez M. Epidemiology of papillomavirus infection: new options for cervical cancer prevention. Salud Pub Mex. 2003;45:326-39.
Dunne EF, Markowitz LE. Genital humann papillomavirus infection. Clin Infect Dis 2006;43:624-9.
Trottier H, Franco EL. The epidemiology of genital human papillomavirus infection. Vaccine 2006;24(supl 1): S1-15.
Sánchez-Alemán MA. Prevalencia y factores asociados a la infección por Treponema pallidum, virus del herpes simple tipo 2 y virus del papiloma humano en estudiantes universitarios (tesis de Maestría). Cuernavaca: Escuela de Salud Pública de México/ Instituto Nacional de Salud Pública, 2001.
Juárez-Figueroa LA, Wheeler CM, Uribe-Salas FJ, Conde-González CJ, Zamilpa-Mejía LG, García-Cisneros S. Human Papillomavirus, a highly prevalent sexually transmitted disease among female sex workers from Mexico City. Sex Transm Dis 2001;28:125-30.
Sam Soto S, Gayón Vera E. Guía práctica para el abordaje y manejo de lesiones anogenitales por virus del papiloma humano en adolescentes. Acta Pediatr Mex 2006;27:151-6.
Armstrong DK, Handley JM. Anogenital warts in prepuberal children: pathogenesis, HPV typing and management. Int J Std Aids 1997;8:1007-8.
Massing AM, Epstein WL. Natural history of warts. A two-year study. Arch Dermatol 1963;87:306-10.
Zhang M. The relation of local immune status to efficacy of immunotherapy in patients with condyloma acuminatum. Sichuan Da Xue Xue Bao Yi Xue Ban 2005;6:559-61.
Barrett TJ, Silber JD, McGinley JP. Genital warts a venereal disease. JAMA 1954;154:333
Myhre AK, Dalen A, Bertzen K. Anogenital human papillomavirus in non-abused preschool child. Acta Pediatr 2003;92:1445-52.
Watts DH, Koutsky LA, Holmes KK. Low risk of perinatal trans-mission of human papillomavirus: results from a prospective cohort study. Am J Obstet Gynecol 1998;178:365-73.
Puramen M, Yliskoski M, Saarikoski S. Vertical transmission of human papillomavirus from infected mothers to their newborn babies and persistence of the virus in childhood. Am J Obstet Gynecol 1996;174:694-9.
Smith EM, Johnson SR, Cripe T. Perinatal transmission and maternal risks of human papillomavirus infection. Cancer Detect Prev 1995;19:196-205.
Stevens-Simon C, MD, Nelligan D, Breese P, Jenny C, Douglas MJ. The prevalence of genital human papillomavirus infections in abused and nonabused preadolescent girls. Pediatrics 2000;106:645-9.
Syrjanen S, Puranen M. Human papillomavirus infections in children: the potential role of maternal transmission. Crit Rev Oral Biol Med 2000;11:259-74.
Tseng CJ, Lin CY, Wang RL. Possible transplacental transmission of human papillomaviruses. Am J Obstet Gynecol 1992;166:35-40.
Pakarian F, Kalle J, Cason J. Cancer – associated human papillomaviruses : perinatal transmission and persistence. Br J Obstet Gyneacol 1994;101:514-17.
Armbruster ME, Ioshimoto LM, Leao E. Presence of human papillomavirus DNA in amniotic fluids of pregnant women with cervical lesions. Gynecol Oncol 1994;54:152-8.
Alberico S, Pinzano R, Comar M. Maternal-fetal transmission of human papillomavirus. Minerva Gynecol 1996;48:199- 204.
Rogo KO, Nyansera PN. Congenital condylomata acuminata with meconium staining of amniotic fluid and fetal hydrocephalus: case report. East Afr Med J 1989;66:411-3.
Tang CK, Shermeta DW, Wood C. Congenital condylomata acuminate. Am J Obstet Gynecol 1978;131:912-3.
Emans JE, Laufer MR, Goldstein DP. Papilomavirus humano en niñas y adolecsentes, con valoración de citología vaginal. En: Ginecología ed Pediatría y la Adolescente. McGraw-Hill Interamericana 4ta Ed. 2000;pp387-424.
Cason J, Kaye JN, Best JM. Non-sexual acquisition of human genital papillomavirus. Papillomavirus Rep 1995;6:1-7.
Obalek S, Jablonska S, Favre M, Walczak L, Orth G. Condyloma acuminata in children: frequent association with human papillomaviruses responsible for coetaneous warts. J Am Acad Dermatol 1990;23:205-13.
Gutman LT, Herman-Giddens ME, Phelps WC Transmission of human genital papillomavirus disease: comparison of data from adults and children. Pediatrics 1993;91:31-8.
Obalek S, Misiewica J, Jablonska S, Childhood condyloma acuminatum: association with genital coetaneous human papillomaviruses. Pediatr Dermatol 1993;10:101-6.
Rivera R. Epidemiología del virus papiloma humano. Rev Chil Obstet Ginecol 2002;67:501-6.
Bergeron C, Ferenczy A, Richard R. Underwear: contamination by human papillomaviruses . Am J Obstet Ginecol 1990;162:25-9.
Johnson LW. Communal showers and the risk of plantar and genital warts. J Fam Pract. 1995;40:136-8.
Pereyra PB, Di Paola G, Mendez RJ. Vulvar infection caused by human papillomavirus in children and adolescents without sexual contact. Adolesc Pediatr Gynecol 1991;4:136-42.
American Academy of Pediatrics and Committee on Child Abuse and Neglect. Guidelines for the evaluation of sexual abuse in children. Pediatrics 2005;116:506-12
Centers for Disease Control: Sexually transmitted diseases,treatment guidelines. 2002 www.cdc.gov/mmwr/preview
Smith EM, McCune KK, Horbach N, Dattel BJ. Incidence and clinical correlates of human papillomaviruses disease in a pediatric population referred for evaluation of sexual abuse. Adolesc Pediatr Gynecol 1993;6:20-4.
Siegfried E, Rasnick-Conley J, Cook S. Human papillomavirus screening in pediatric victims of sexual abuse. Pediatrics 1998;101:47-7.
Nowicky MJ. Diagnosis: Condyloma acuminatum. J Pediatr Gastroenterol Nutr 2005;40:382-5.
Eyer de Jesus L, Lima E, Cirne Neto OL, Monteiro de Nascimento LM. Anogenital warts in children: Sexual abused or unintentional contamination? Cad Saùde Pùblica 2001;17:1383-91.
Carolyn YM, Harriet OS. Cervical neoplasia complicating pregnancy. Obstet Gynecol Clin N Am 2005;32:533–46.
Brown D, Berran P, Kaplan KJ. Special situations: abnormal cervical cytology during pregnancy. Clin Obstet Gynecol 2005;48:178– 85.
Kulasingam SL, Hughes JP, Kiviat NB, Mao C, Weiss NS, Kuypers JM. Evaluation of human papillomavirus testing in primaryscreening for cervical abnormalities: comparison of sensitivity,specificity, and frequency of referral. JAMA 2002;288:1749-57.
Kristin M, Jessica A. Human papillomavirus and adolescent girls. Current Women’s Health 2002;2:468-75.
Lahoti SL, McClain NR, Girardet R, Meneses M, Cheung K. Evaluating the child for sexual abusse. American Family Physician 2001;63:883-92.
Perea Martínez A, Loredo-Abdalá A, Monroy Villafuerte A,Güicho Alba El Abuso Sexual: del silencio ignominioso auna realidad estigmatizante. En: Loredo-Abdalá Maltrato en Niños y Adolescentes. Editores de Textos Mexicanos. México 2004;pp75-102.
Buck HW. Genital warts. Clin Evid 2006;15:2149-61
Kumaran MS. Anogenital warts in an infant. J Eur Acad Dermatol Venereol 2005;19:782-3.
De Villiers EM, Whitley C, Gunst K. Identification of new papillomavirus types. Methods Mol Med 2005;119:1-13.
Ergünay K, Misirlio lu M, Pinar F, Tuncer ZS, Tuncer S, Ustaçelebi S. Investigation of human papilloma virus DNA in cervical samples with cytological abnormalities and typing of the virus Mikrobiyol Bul. 2007;41:219-26