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Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

2006, Number 5

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Rev Invest Clin 2006; 58 (5)

The effect of MTHFR polymorphisms, pregnancy and first intercourse on cervical cancer in a population from the Northeastern Mexico

Delgado-Enciso I, Martínez-Garza SG, Rojas-Martínez A, Espinoza-Gómez F, Canseco-Avila LM, Vidal-Gutiérrez O, Garza-Leal JG, Barboza-Quintana O, Flores-Gutiérrez JP, Barrera-Saldaña HA, Ortiz-López R

Language: Spanish
References: 50
Page: 462-469
PDF size: 74.36 Kb.


ABSTRACT

Objective. To investigate the possible association among MTHFR polymorfhisms, environmental factors and cervical cancer (CC) in the Mexican population. Methods. Seventy patients with CC and 89 control women were questioned about clinical data and their 677 and 1298 genotypes of MTHFR gene were analized. Results. Multipregnancies (0-2 vs. ≥ 3, OR 2.1), an early age of first intercourse (IVS) (17 ≤ vs. ≥ 18 years, OR 4.3) or both factors (OR 3.5) were significantly associated with CC. MTHFR 677, 1298 polymorphisms and their combinations were not different between cases and controls. However, a significant association between pregnancies, IVS and MTHFR polymorphisms (presence of 1298C allele or 677TT genotype) was observed. The 1298C allele plus multipregnancies and IVS ≤ 17 years, or both factors, increased 4.3, 5.3, and 11.8 times the risk for CC, respectively, while 677TT genotype changed the risk 2.0, 1.9, and 4.2 times, respectively. Conclusion. The 1298C allele increases the risk of CC strongly in women with multipregnancies and early age of IVS, while 677TT genotype has a lower risk without becoming a protection factor.


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