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Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

2006, Número 5

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Rev Invest Clin 2006; 58 (5)


Interacciones entre polimorfismos del gen MTHFR, gestaciones e inicio de vida sexual modifican el riesgo para cáncer cérvico-uterino en una población del noreste de México

Delgado-Enciso I, Martínez-Garza SG, Rojas-Martínez A, Espinoza-Gómez F, Canseco-Avila LM, Vidal-Gutiérrez O, Garza-Leal JG, Barboza-Quintana O, Flores-Gutiérrez JP, Barrera-Saldaña HA, Ortiz-López R

Idioma: Español
Referencias bibliográficas: 50
Paginas: 462-469
Archivo PDF: 74.36 Kb.


RESUMEN

Objetivo. Buscar la asociación entre polimorfismos de la enzima metilentetrahidrofolato reductasa (MTHFR), factores ambientales y cáncer cérvico-uterino (CaCU) en mujeres del noreste de México. Métodos. Setenta pacientes con CaCU y 89 mujeres controles se sometieron a un interrogatorio clínico y a genotipificación de los polimorfismos 677C→T y 1298A→C del gen MTHFR. Resultados. La multigestación (0-2 vs. ≥ 3, OR 2.1), un temprano inicio de vida sexual (IVS) (17 ≤ vs. ≥ 18 años, OR 4.3) o la combinación de ambos factores (OR 3.5), estuvieron asociados significativamente al CaCU. Los polimorfismos de MTHFR 677, 1298 y sus combinaciones no fueron diferentes entre casos y controles. Sin embargo, se observó una interacción significativa entre las gestaciones, el IVS y los polimorfismos de MTHFR (presencia del alelo 1298C o del genotipo 677TT). El alelo 1298C combinado con multigestación, con un IVS ≤ 17 años, o con ambos factores, incrementó el riesgo para CaCU en 4.3, 5.3 y 11.8 veces, respectivamente, en tanto que el genotipo 677TT modificó este riesgo a 2.0, 1.9, y 4.2 veces, respectivamente. Conclusión. El alelo 1298C incrementa considerablemente el riesgo para CaCU en mujeres multigestas y con un IVS temprano, en tanto que el genotipo 677TT disminuye este riesgo, pero sin llegar a convertirse en un factor protector.


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